Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
International survey of T2* cardiovascular magnetic resonance in β-thalassemia major
Haematologica, Volume 98, No. 9, Year 2013
Notification
URL copied to clipboard!
Description
Accumulation of myocardial iron is the cause of heart failure and early death in most transfused thalassemia major patients. T2* cardiovascular magnetic resonance provides calibrated, reproducible measurements of myocardial iron. However, there are few data regarding myocardial iron loading and its relation to outcome across the world. A survey is reported of 3,095 patients in 27 worldwide centers using T2* cardiovascular magnetic resonance. Data on baseline T2* and numbers of patients with symptoms of heart failure at first scan (defined as symptoms and signs of heart failure with objective evidence of left ventricular dysfunction) were requested together with more detailed information about patients who subsequently developed heart failure or died. At first scan, 20.6% had severe myocardial iron (T2*≤10ms), 22.8% had moderate myocardial iron (T2* 10-20ms) and 56.6% of patients had no iron loading (T2*>20ms). There was significant geographical variation in myocardial iron loading (24.8-52.6%; P<0.001). At first scan, 85 (2.9%) of 2,915 patients were reported to have heart failure (81.2% had T2* <10ms; 98.8% had T2* <20ms). During follow up, 108 (3.8%) of 2,830 patients developed new heart failure. Of these, T2* at first scan had been less than 10ms in 96.3% and less than 20ms in 100%. There were 35 (1.1%) cardiac deaths. Of these patients, myocardial T2* at first scan had been less than 10ms in 85.7% and less than 20ms in 97.1%. Therefore, in this worldwide cohort of thalassemia major patients, over 43% had moderate/severe myocardial iron loading with significant geographical differences, and myocardial T2* values less than 10ms were strongly associated with heart failure and death. © 2013 Ferrata Storti Foundation.
Authors & Co-Authors
Carpenter, John Paul
Unknown Affiliation
Roughton, Michael
Unknown Affiliation
Pennell, Dudley John
Unknown Affiliation
He, Taigang
Unknown Affiliation
Kirk, Paul
Unknown Affiliation
Anderson, Lisa J.
Unknown Affiliation
Porter, John B.
Unknown Affiliation
Malcolm Walker, J.
Unknown Affiliation
Galanello, Renzo
Unknown Affiliation
Danjou, Fabrice
Unknown Affiliation
Forni, G. L.
Unknown Affiliation
Kattamis, Antonis C.
Unknown Affiliation
Ladis, Vassilis
Unknown Affiliation
Drossou, Marouso
Unknown Affiliation
Vini, Demetra
Unknown Affiliation
Michos, Andreas
Unknown Affiliation
Perifanis, Vassilios
Unknown Affiliation
Hazirolan, Tuncay
Unknown Affiliation
Almeida, Ana
Unknown Affiliation
Aydınok, Yeşim
Unknown Affiliation
Bayraktaroǧlu, Selen
Unknown Affiliation
Rangelova, Mirella
Unknown Affiliation
Stoyanova, Denka
Unknown Affiliation
Kaleva, Valeria I.
Unknown Affiliation
Tonev, Georgi
Unknown Affiliation
El-Beshlawy, Amal M.
Unknown Affiliation
ElAlfy, Mohsen Saleh
Unknown Affiliation
al-Nasser, Ibrahim
Unknown Affiliation
Au, Wing Yan
Unknown Affiliation
Ha, S. Y.
Unknown Affiliation
Li, Chi Kong
Unknown Affiliation
Chu, Winnie C.
Unknown Affiliation
Chan, Lee Lee
Unknown Affiliation
Lu, Meng Yao
Unknown Affiliation
Wahidiyat, Lia
Unknown Affiliation
Merelles-Pulcini, Manuela
Unknown Affiliation
Fernandes, Juliano de Lara
Unknown Affiliation
Kay, Fernando
Unknown Affiliation
Joy Ho, Phoebe
Unknown Affiliation
Hankins, Jane S.
Unknown Affiliation
Cappellini, Maria Teresa
Unknown Affiliation
Daar, Shahina F.
Unknown Affiliation
Sathar, Jameela
Unknown Affiliation
Taher, Ali T.
Unknown Affiliation
Kontoghiorges, George
Unknown Affiliation
Belhoul, Khawla M.
Unknown Affiliation
Thompson, Alexis A.
Unknown Affiliation
Kwiatkowski, Janet L.
Unknown Affiliation
Tan, Ru San
Unknown Affiliation
Thuret, Isabelle
Unknown Affiliation
Badens, Catherine
Unknown Affiliation
Statistics
Citations: 63
Authors: 51
Affiliations: 43
Identifiers
Doi:
10.3324/haematol.2013.083634
ISSN:
03906078
e-ISSN:
15928721
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative