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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Emergence and persistence of nevirapine resistance in breast milk after single-dose nevirapine administration
AIDS, Volume 24, No. 4, Year 2010
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Description
Objective: Single-dose nevirapine (NVP) (sdNVP) can reduce the risk of HIV vertical transmission. We assessed risk factors for NVP resistance in plasma and breast milk from sdNVP-exposed Ugandan women. Methods: Samples were analyzed using the Roche AMPLICOR HIV-1 Monitor Test Kit, version 1.5, and the ViroSeq HIV-1 Genotyping System. NVP concentrations were determined by liquid chromatography with tandem mass spectroscopy. Results: HIV genotypes (plasma and breast milk) were obtained for 30 women 4 weeks after sdNVP (HIV subtypes: 15A, 1C, 12D, two recombinant). NVP resistance was detected in 12 (40%) of 30 breast milk samples. There was a nonsignificant trend between detection of NVP resistance in breast milk and plasma (P = 0.06). There was no association of HIV resistance in breast milk with median maternal pre-NVP viral load or CD4 cell count, median breast milk viral load at 4 weeks, breast milk sodium more than 10 mmol/l, HIV subtype, or concentration of NVP in breast milk or plasma. Conclusion: NVP resistance was frequently detected in breast milk 4 weeks after sdNVP exposure. In this study, we were unable to identify specific factors associated with breast milk NVP resistance. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Hudelson, Sarah E.
United States, Baltimore
Johns Hopkins School of Medicine
McConnell, Michelle S.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Bagenda, Danstan S.
Uganda, Kampala
Makerere University
Piwowar-Manning, Estelle M.
United States, Baltimore
Johns Hopkins School of Medicine
Parsons, Teresa L.
United States, Baltimore
Johns Hopkins School of Medicine
Nolan, Monica L.
Unknown Affiliation
Bakaki, Paul M.
United States, Cleveland
Case Western Reserve University
Thigpen, Michael C.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Mubiru, Michael Charles
Uganda, Kampala
Makerere University
Fowler, Mary Glenn
United States, Baltimore
Johns Hopkins School of Medicine
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
Statistics
Citations: 19
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e3283346e60
e-ISSN:
14735571
Research Areas
Infectious Diseases
Maternal And Child Health
Participants Gender
Female