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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
First-Trimester Maternal Serum Adiponectin/Leptin Ratio in Pre-Eclampsia and Fetal Growth
Life, Volume 13, No. 1, Article 130, Year 2023
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Description
The serum adiponectin/leptin ratio (A/L ratio) is a surrogate marker of insulin sensitivity. Pre-eclampsia (PE) is associated with maternal metabolic syndrome and occasionally impaired fetal growth. We assessed whether the A/L ratio in first-trimester maternal serum was associated with PE and/or birth weight. Adiponectin and leptin were quantitated in first-trimester blood samples (gestational week 10+3–13+6) from 126 women who later developed PE with proteinuria (98 mild PE; 21 severe PE; 7 HELLP syndrome), and 297 controls, recruited from the Copenhagen First-Trimester Screening Study. The A/L ratio was reduced in PE pregnancies, median 0.17 (IQR: 0.12–0.27) compared with controls, median 0.32 (IQR: 0.19–0.62) (p < 0.001). A multiple logistic regression showed that PE was negatively associated with log A/L ratio independent of maternal BMI (odds ratio = 0.315, 95% CI = 0.191 to 0.519). Adiponectin (AUC = 0.632) and PAPP-A (AUC = 0.605) were negatively associated with PE, and leptin (AUC = 0.712) was positively associated with PE. However, the A/L ratio was a better predictor of PE (AUC = 0.737), albeit not clinically relevant as a single marker. No significant association was found between A/L ratio and clinical severity of pre-eclampsia or preterm birth. PE was associated with a significantly lower relative birth weight (p < 0.001). A significant negative correlation was found between relative birth weight and A/L ratio in controls (β = −0.165, p < 0.05) but not in PE pregnancies), independent of maternal BMI. After correction for maternal BMI, leptin was significantly associated with relative birth weight (β = 2.98, p < 0.05), while adiponectin was not significantly associated. Our findings suggest that an impairment of the A/L ratio (as seen in metabolic syndrome) in the first trimester is characteristic of PE, while aberrant fetal growth in PE is not dependent on insulin sensitivity, but rather on leptin-associated pathways. © 2023 by the authors.
Authors & Co-Authors
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
Placing, Sophie
Denmark, Copenhagen
Statens Serum Institut
Wøjdemann, Karen Reinhold
Unknown Affiliation
Shalmi, Anne Cathrine
Denmark, Hillerod
Nordsjællands Hospital - Hillerød
Rode, Line
Denmark, Copenhagen
Rigshospitalet
Kanters, Jörgen Kim
Denmark, Copenhagen
Københavns Universitet
Sundberg, Karin M.
Denmark, Copenhagen
Copenhagen University Hospital
Tabor, Ann
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Lausten-Thomsen, Ulrik
Denmark, Copenhagen
Rigshospitalet
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Statistics
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.3390/life13010130
ISSN:
20751729
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Case-Control Study
Participants Gender
Female