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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Incidence of infections due to Escherichia coli strains producing extended spectrum betalactamase, in the Zou/Collines Hospital Centre (CHDZ/C) in Benin
Medecine et Maladies Infectieuses, Volume 37, No. 11, Year 2007
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Description
Objectives: Over a 6-month period, extended-spectrum betalactamase (ESBL)-producing isolates of Escherichia coli (EC) were collected from in-patients and their environment at the Zou-Collines Hospital Centre (CHDZ/C) in Benin. The aim of this study was to determine the incidence of ESBL and to describe their phenotypic susceptibility to antibiotics in a secondary hospital (500 beds) in Benin. Methods: From 15 May to 15 November 2005, clinical informations and samples were collected from patients suspected to have nosocomial infections. The isolates were identified, tested for antimicrobial susceptibility and analysed for the presence of ESBL genes blaTEM and blaSHV by PCR. Results: One hundred ninety-seven enterobacteria were isolated from the clinical samples of 342 patients, these isolates included 143 EC and 32/143 (22%) of these isolates produced ESBL. Forty-six EC were isolated from the environment and 7 (15%) of them produced ESBL. Except for Imipenem for which the difference was not significant, the isolates producing ESBL were more resistant to the other antibiotics (especially to third generation cephalosporins: Ceftriaxone, Cefotaxime, Ceftazidime (P < 0.00001)) than non-ESBL producing isolates. Both ESBL genes blaSHV and blaTEM were identified in the EC ESBL strains from patient and from the environment. Conclusion: This study shows the presence of ESBL genes among EC in various wards of the CHDZ/C hospital proving that there is a need to implement a strict hospital infection control program and a regular surveillance of resistance to antimicrobial agents. © 2007 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Ahoyo, A. T.
Benin, Cotonou
University of Abomey-calavi
Baba-Moussa, Lamine Saïd
Benin, Cotonou
University of Abomey-calavi
Anago, A. E.
Benin, Cotonou
École Polytechnique D'abomey-calavi Epac/uac
Avogbe, Patrice Hodonou
Benin, Cotonou
University of Abomey-calavi
Missihoun, T. D.
Benin, Cotonou
University of Abomey-calavi
Loko, F.
Benin, Cotonou
École Polytechnique D'abomey-calavi Epac/uac
Prévost, Gilles
France, Strasbourg
Université de Strasbourg
Sanni, Ambaliou
Benin, Cotonou
University of Abomey-calavi
Dramane, Karim L.
Benin, Cotonou
University of Abomey-calavi
Statistics
Citations: 38
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.medmal.2007.03.004
ISSN:
0399077X
Research Areas
Health System And Policy
Study Design
Cohort Study
Study Locations
Benin