Evaluation of malondialdehyde, vitamin C and reduced glutathion levels in pre and post Hémodialysis patients

Oxidative stress often occurs in chronic hemodialysis. The aim of the present study was to evaluate the level of vitamin C, reduced glutathione and malondialdehyde products of lipid peroxidation in a group of patients on haemodialysis at the Douala General Hospital. Twenty-six patients (13 males and 13 females) on dialysis twice per week and twenty-six healthy subjects corresponding to the control group (13 males and 13 females) were recruited. The results showed significantly higher level (p<0.05) of malondialdéhyde (MDA) after haemodialysis compared to a control group. In addition, the vitamin C levels decrease significantly after haemodialysis (p < 0.05). The level of reduced glutathione before haemodialysis was significantly low compared to the control group but increased significantly after haemodialysis. We also found that there was a significant positive correlation (p < 0.05) between MDA and vitamin C after a hemodialysis session.