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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cryptococcus neoformans-reactive and total immunoglobulin profiles of human immunodeficiency virus-infected and uninfected Ugandans
Clinical and Diagnostic Laboratory Immunology, Volume 12, No. 10, Year 2005
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Description
We determined total and Cryptococcus neoformans glucuronoxylomannan (GXM)-reactive antibody repertoires of human immunodeficiency virus (HIV)-infected and HIV-uninfected Ugandans in a retrospective, case-control study of participants in a randomized controlled trial of pneumococcal vaccination. The study included 192 adults: 48 who subsequently developed cryptococcal meningitis (CM); (HIV+ CM+); 2 individuals who matched them in CD4+ T-cell level, stage of HIV disease, and age but did not develop CM (HIV+ CM-); and 48 HIV-uninfected individuals. Total serum immunoglobulin concentrations and titers of immunoglobulin M (IgM), IgG, and IgA to GXM, pneumococcal polysaccharides, and antibodies expressing certain VH3 idiotypes were determined with banked sera obtained before the development of cryptococcosis for HIV + CM+ subjects. The results showed that HIV-infected subjects had significantly lower levels of IgM to GXM but higher levels of total immunoglobulin and IgG and IgA to GXM than those of HIV-uninfected subjects. HIV-infected subjects with a history of pneumonia had higher levels, and those with a history of herpes zoster had lower levels of GXM-binding antibodies than subjects with no history of either disease. Minimal to no cross-reactivity was demonstrated between antibodies to GXM and polysaccharides in a pneumococcal vaccine. No significant differences between the antibody repertoires of HIV + CM+ and HIV+ CM- subjects were identified, but among subjects without a history of pneumonia, there was a trend towards lower VH3-positive antibody levels among HIV+ CM+ than among HIV+ CM- subjects. Our findings demonstrate an association between previous infectious diseases and differences in the total and GXM-reactive antibody repertoires of HIV-infected subjects and suggest the question of whether certain microbes modulate subsequent antibody responses to GXM deserves further study. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Subramaniam, Krishanthi S.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
French, N.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Uganda
Medical Research Council Programme on Aids
Pirofski, Liise Anne
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 33
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1128/CDLI.12.10.1168-1176.2005
ISSN:
1071412X
Research Areas
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative