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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine
American Journal of Tropical Medicine and Hygiene, Volume 81, No. 4, Year 2009
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Description
In a placebo controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4 months post treatment) on depletion of Wolbachia endobacteria from Wuchereria bancrofti, filaricidal activity, and amerlioration of scrotal lymph vessel dilation were studied in 57 men from Orissa, India. The 21-day doxycycline course reduced Wolbachia in W. bancrofti by 94% before diethylcarbamazine administration. After 12 months, all patients with this treatment were amicrofilaremic and different from the 10-day doxycycline (42.9%) and placebo (37.5%) groups, and significantly fewer were positive for scrotal worm nests (6.7%) compared with 10-day doxycycline (60%) and placebo (66.7%). Average scrotal lymph vessel diameters were reduced from 0.7 cm pre-treatment to 0.02 cm in patients after 21 days of treatment, while no significant changes were seen in the other groups. This latter feature confirms the beneficial effects of doxycycline on lymphatic dilation and thus adds to the existing evidence that doxycycline, in addition to being macrofilaricidal, may be used to prevent or reverse lymphatic pathology. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Mand, Sabine
Germany, Bonn
Universitätsklinikum Bonn
Pfarr, Kenneth M.
Germany, Bonn
Universitätsklinikum Bonn
Sahoo, Prakash Kumar
India, Bhubaneswar
Regional Medical Research Centre, Bhubaneswar
Satapathy, Ashok Kumar
India, Bhubaneswar
Regional Medical Research Centre, Bhubaneswar
Specht, Sabine
Germany, Bonn
Universitätsklinikum Bonn
Klarmann-Schulz, Ute
Germany, Bonn
Universitätsklinikum Bonn
Debrah, Yaw Alex
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Ravindran, Balachandran
India, Bhubaneswar
Institute of Life Sciences India
Hoerauf, Achim M.
Germany, Bonn
Universitätsklinikum Bonn
Statistics
Citations: 69
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2009.09-0155
ISSN:
00029637
Research Areas
Health System And Policy
Participants Gender
Male