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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
High density lipoprotein-anionic peptide factor effect on reverse cholesterol transport in type 2 diabetic patients with and without coronary artery disease
Clinical Biochemistry, Volume 43, No. 13-14, Year 2010
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Description
Objectives: To verify if HDL3 Anionic Peptide Factor (HDL3-APF) is as an apolipoprotein that promotes the reverse cholesterol transport. Design and methods: We investigated a possible association between plasma HDL3-APF concentration, cholesterol efflux from Fu5AH cells and cholesteryl ester transfer protein (CETP) activity in type 2 diabetic patients with coronary artery disease (CAD) (n=36), those without CAD (n=20), and 37 healthy subjects. Results: Plasma APF concentrations were decreased in diabetics with CAD compared to controls (p<0.01). Cellular cholesterol efflux was decreased in diabetics without and with CAD, (p<0.01 and p<0.001 respectively). CETP activity was significantly elevated in all patient groups. Multiple linear regression analysis shows that cholesterol efflux was independently and positively related only to APF concentrations in controls. Conclusions: APF is likely to be a key independent factor for promoting cellular cholesterol efflux in healthy subjects. However this association is altered in type 2 diabetes. © 2010 The Canadian Society of Clinical Chemists.
Authors & Co-Authors
Attia, Nebil
Tunisia, Monastir
Faculté de Médecine de Monastir
Tunisia, Tunis
University of Carthage
Lorec, Anne Marie
France, Paris
Inserm
France, Marseille
Hôpital Sainte Marguerite
Domingo, Nicole
France, Paris
Inserm
Nakbi, Amel
Tunisia, Monastir
Faculté de Médecine de Monastir
Hammami, Sonia Ouali
Tunisia, Monastir
Faculté de Médecine de Monastir
Ben-Hamda, Khaldoun
Tunisia, Monastir
Faculté de Médecine de Monastir
Châaba, Raja
Tunisia, Monastir
Faculté de Médecine de Monastir
Masmoudi, Ahmed Slaheddine
Tunisia, Monastir
Faculté de Médecine de Monastir
Moulin, Philippe
France, Lyon
Hopital Louis Pradel
Portugal, Henri
France, Paris
Inserm
France, Marseille
Hôpital Sainte Marguerite
Lairon, Denis
France, Paris
Inserm
Chanussot, Françoise
France, Paris
Inserm
Hammami, M. B.
Tunisia, Monastir
Faculté de Médecine de Monastir
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1016/j.clinbiochem.2010.06.010
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Approach
Quantitative