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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human polyomaviruses, WU and KI in HIV exposed children with acute lower respiratory tract infections in hospitals in South Africa
Journal of Clinical Virology, Volume 44, No. 3, Year 2009
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Description
Background: The importance of two recently identified polyomaviruses, WUV and KIV, as respiratory pathogens in populations with a high HIV prevalence needs to be defined, since human polyomaviruses can cause significant morbidity and mortality in patients with immunosuppression. Geographic distribution and disease association of WUV and KIV genotypes are not yet clearly defined. Objectives: To investigate the prevalence of WUV and KIV in HIV-positive and HIV-negative patients with respiratory infections in hospitals in South Africa and determine their genotypes. Study design: Specimens from patients with acute respiratory infections from hospitals serving Pretoria were screened for WUV and KIV. Positive specimens were sequenced and subjected to phylogenetic analysis. Results: WUV was identified in (7%) and KIV in (1%) of mainly pediatric patients. Co-infections were common in WUV- and KIV-infected patients (71% and 66.6%, respectively); 57% of patients with WUV and 33% of patients with KIV were HIV-positive while the HIV prevalence in the respiratory virus patient group screened in this study was 33% WUV and KIV patients presented with moderate to severe lower respiratory tract disease. Four distinct and 2 unique WUV strains were identified clustering into 2 of 4 globally identified genotypes. KIV strains were identical to strains from Sweden. Conclusion: WUV is frequently detected in HIV-infected patients with respiratory disease, but its role as respiratory pathogen remains uncertain. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Venter, Marietjie
South Africa, Pretoria
University of Pretoria
South Africa, Johannesburg
National Health Laboratory Service
Visser, Adele
South Africa, Pretoria
University of Pretoria
South Africa, Johannesburg
National Health Laboratory Service
Lassaunière, Ria
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 35
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.jcv.2008.12.007
ISSN:
13866532
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
South Africa