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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lipodystrophy and weight changes: Data from the Swiss HIV Cohort Study, 2000-2006
HIV Medicine, Volume 9, No. 3, Year 2008
Notification
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Description
Background and Objectives: Combination antiretroviral therapy (cART) is changing, and this may affect the type and occurrence of side effects. We examined the frequency of lipodystrophy (LD) and weight changes in relation to the use of specific drugs in the Swiss HIV Cohort Study (SHCS). Methods: In the SHCS, patients are followed twice a year and scored by the treating physician as having 'fat accumulation', 'fat loss', or neither. Treatments, and reasons for change thereof, are recorded. Our study sample included all patients treated with cART between 2003 and 2006 and, in addition, all patients who started cART between 2000 and 2003. Results: From 2003 to 2006, the percentage of patients taking stavudine, didanosine and nelfinavir decreased, the percentage taking lopinavir, nevirapine and efavirenz remained stable, and the percentage taking atazanavir and tenofovir increased by 18.7 and 22.2%, respectively. In life-table Kaplan-Meier analysis, patients starting cART in 2003-2006 were less likely to develop LD than those starting cART from 2000 to 2002 (P < 0.02). LD was quoted as the reason for treatment change or discontinuation for 4% of patients on cART in 2003, and for 1% of patients treated in 2006 (P for trend < 0.001). In univariate and multivariate regression analysis, patients with a weight gain of ≥5kg were more likely to take lopinavir or atazanavir than patients without such a weight gain [odds ratio (OR) 2, 95% confidence interval (CI) 1.3-2.9, and OR 1.7, 95%; CI 1.3-2.1, respectively]. Conclusions: LD has become less frequent in the SHCS from 2000 to 2006. A weight gain of more than 5kg was associated with the use of atazanavir and lopinavir. © 2008 British HIV Association.
Authors & Co-Authors
Calmy, Alexandra L.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Bernasconi, Enos
Switzerland, Lugano
Hospital of Lugano
Battegay, Manuel
Switzerland, Basel
Universitätsspital Basel
Opravil, Milos
Switzerland, Zurich
Universitatsspital Zurich
Tarr, Philip E.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Schmid, Patrick
Unknown Affiliation
Perneger, Thomas V.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Hirschel, B. J.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Bürgisser, Ph
Unknown Affiliation
Calmy, Alexandra
Unknown Affiliation
Cavassini, Matthias L.
Unknown Affiliation
Dubs, Rolf W.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Erb, Peter
Unknown Affiliation
Fischer, Marek
Unknown Affiliation
Flepp, Markus J.
Unknown Affiliation
Fontana, Adriano
Unknown Affiliation
Francioli, Patrick B.
Unknown Affiliation
Furrer, Hansjakob
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hirschel, B.
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Karrer, Urs
Unknown Affiliation
Kind, Christian H.
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martinez, Begogna
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Paccaud, Fred Michel
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Rickenbach, Martin
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Schültze, Detlev
Unknown Affiliation
Schüpbach, Jörg Rg
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 72
Authors: 51
Affiliations: 6
Identifiers
Doi:
10.1111/j.1468-1293.2007.00537.x
ISSN:
14642662
Research Areas
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative