Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application
Journal of Polymers and the Environment, Volume 19, No. 4, Year 2011
Notification
URL copied to clipboard!
Description
A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze-thawed process was studied. Results obtained disclose that the swelling percent of the hydrogels is pH- dependent and increases by increasing the chitosan percent and decreases with increasing the time and number of freezing cycle. With respect to the antimicrobial activity of the prepared hydrogels, display a positive effect for both gram positive and gram negative bacteria. Freeze-thawed hydrogels could serve as drug delivery system to release sparfloxacin in acidic medium. Indeed, the release percent of sparfloxacin relies on both pH and temperature. © 2011 Springer Science+Business Media, LLC.
Authors & Co-Authors
Abdel-Mohsen, A. M.
Czech Republic, Pardubice
Univerzita Pardubice
Egypt, Giza
National Research Centre
Aly, Aly Sayed
Egypt, Giza
National Research Centre
Hrdina, Radim
Czech Republic, Pardubice
Univerzita Pardubice
Montaser, A. S.
Egypt, Giza
National Research Centre
Hebeish, Ali Ali
Egypt, Giza
National Research Centre
Statistics
Citations: 104
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1007/s10924-011-0334-0
ISSN:
15662543
Research Areas
Environmental
Substance Abuse