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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic polymorphisms in the egfr (R521K) and estrogen receptor (T594T) genes, EGFR and erbb-2 protein expression, and breast cancer risk in tunisia
Journal of Biomedicine and Biotechnology, Volume 2009, Article 753683, Year 2009
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Description
We evaluated the association of epidermal growth factor receptor (EGFR) 142285GA (R521K) and estrogen receptor alpha (ESR1) 2014GA (T594T) single nucleotide polymorphisms with breast cancer risk and prognosis in Tunisian patients. EGFR 142285GA and ESR1 2014GA were genotyped in a sample of 148 Tunisian breast cancer patients and 303 controls using PCR-RFLP method. Immunohistochemitsry was used to evaluate the expression levels of EGFR, HER2, ESR1, progesterone receptor and BCL2 in tumors. We found no evidence for an association between EGFR R521K polymorphism and breast cancer risk. However, we found that the homozygous GG (Arg) genotype was more prevalent in patients with lymph node metastasis (P =.03) and high grade tumors (P =.011). The ESR1 2014G allele showed significant association with breast cancer risk (P =.025). The GG genotype was associated with HER2 overexpression and this association withstood univariate and multivariate analyses (P =.009; P =.021, resp.). These data suggest that the R521K might be a prognostic factor, because it correlates with both tumor grade and nodule status. The higher expression of HER2 in ESR1 T594T GG patients suggests the possibility that ESR1 gene polymorphisms accompanied by HER2 expression might influence the pathogenesis of breast cancers. Copyright © 2009 Reba Ahmed et al.
Authors & Co-Authors
Rebaї, Ahmed
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Kallel, Imen
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Rebaï, Maha
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Khabir, Abdelmajid
Tunisia, Sfax
Chu Habib Bourguiba
Farid, Nadir R.
United Kingdom, Watford
Osancor Biotech Inc.
Statistics
Citations: 28
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1155/2009/753683
ISSN:
11107243
e-ISSN:
11107251
Research Areas
Cancer
Genetics And Genomics
Study Locations
Tunisia