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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene
International Journal for Parasitology, Volume 41, No. 12, Year 2011
Notification
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Description
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya. © 2011 Australian Society for Parasitology Inc.
Authors & Co-Authors
Cupit, Pauline M.
United States, Albuquerque
The University of new Mexico
Steinauer, Michelle L.
United States, Corvallis
Oregon State University
Tonnessen, Bradley W.
United States, Albuquerque
The University of new Mexico
Eric Agola, L.
Kenya, Nairobi
Kenya Medical Research Institute
Kinuthia, Joseph M.
Kenya, Nairobi
Kenya Medical Research Institute
Mwangi, Ibrahim Ndungu
Kenya, Nairobi
Kenya Medical Research Institute
Mutuku, Martin W.
Kenya, Nairobi
Kenya Medical Research Institute
Mkoji, Gerald M.
Kenya, Nairobi
Kenya Medical Research Institute
Loker, Eric Samuel
United States, Albuquerque
The University of new Mexico
Cunningham, Charles
United States, Albuquerque
The University of new Mexico
Statistics
Citations: 18
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijpara.2011.07.007
ISSN:
00207519
e-ISSN:
18790135
Research Areas
Disability
Genetics And Genomics
Infectious Diseases
Study Locations
Kenya