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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides
Journal of Combinatorial Chemistry, Volume 8, No. 2, Year 2006
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Description
CM (ChemMatrix) resin is a new, totally poly(ethylene glycol) (PEG)-based resin, made exclusively from primary ether bonds and, therefore, highly chemically stable. It exhibits good loading and is user-friendly because of its free-flowing form upon drying. It performs excellently for the preparation of hydrophobic, highly structured, and poly-Arg peptides, as compared to polystyrene (PS) resins. In the most striking example, stepwise solid-phase assembly of the highly complex β-amyloid (1-42) peptide resulted in a crude material of 91% purity. In contrast, literature procedures using PS or PEG-PS-based resins for this peptide required convergent approaches, additional time-consuming steps, or both. In addition to the difficulties of its synthesis, characterization of the β-amyloid (1-42) peptide as a monomer is also a challenge, and methods for characterization by HPLC and MALDI-TOF have also been developed. © 2006 American Chemical Society.
Authors & Co-Authors
García-Martín, Fayna
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
García-Ramos, Yésica
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Cruz, Luis Javier
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Tulla-Puche, Judit
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Alberício, Fernando
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 233
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1021/cc0600019
ISSN:
15204766