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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection
Journal of Experimental Medicine, Volume 206, No. 13, Year 2009
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Description
Th2 cells drive protective immunity against most parasitic helminths, but few mechanisms have been demonstrated that facilitate pathogen clearance. We show that IL-4 and IL-13 protect against intestinal lumen-dwelling worms primarily by inducing intestinal epithelial cells (IECs) to differentiate into goblet cells that secrete resistin-like molecule (RELM) β. RELM-β is essential for normal spontaneous expulsion and IL-4-induced expulsion of Nippostrongylus brasiliensis and Heligmosomoides polygyrus, which both live in the intestinal lumen, but it does not contribute to immunity against Trichinella spiralis, which lives within IEC. RELM-β is nontoxic for H. polygyrus in vitro but directly inhibits the ability of worms to feed on host tissues during infection. This decreases H. polygyrus adenosine triphosphate content and fecundity. Importantly, RELM-β-driven immunity does not require T or B cells, alternative macrophage activation, or increased gut permeability. Thus, we demonstrate a novel mechanism for host protection at the mucosal interface that explains how stimulation of epithelial cells by IL-4 and IL-13 contributes to protection against parasitic helminthes that dwell in the intestinal lumen. © 2009 Herbert et al.
Authors & Co-Authors
Herbert, De'Broski R.
United States
Va Medical Center
United States, Cincinnati
University of Cincinnati College of Medicine
Yang, Jun Qi
United States, Cincinnati
University of Cincinnati
Hogan, Simon P.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Groschwitz, Kathryn
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Khodoun, Marat
United States
Va Medical Center
United States, Cincinnati
University of Cincinnati College of Medicine
Munitz, Ariel
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Orekov, Tatyana
United States
Va Medical Center
United States, Cincinnati
University of Cincinnati College of Medicine
Perkins, Charles
United States
Va Medical Center
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Wang, Quan
United States, Cincinnati
University of Cincinnati College of Medicine
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Urban Jr, Joseph F.
United States, Beltsville
Usda Ars Beltsville Human Nutrition Research Center
Rothenberg, Marc E.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Finkelman, Fred D.
United States
Va Medical Center
United States, Cincinnati
University of Cincinnati College of Medicine
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Statistics
Citations: 13
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1084/jem.20091268
ISSN:
00221007
e-ISSN:
15409538