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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Peroxisome proliferator-activated receptor α deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: Modulation of T cell differentiation
Endocrinology, Volume 147, No. 9, Year 2006
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Description
We assessed the implication of peroxisome proliferator-activated receptor (PPAR) α deficiency in pregnancy outcome and neonatal survival and in the modulation of T cell differentiation in murine diabetic pregnancy and their offspring. Pregnant wild-type (WT) and PPARα-null mice of C57BL/6J genetic background were rendered diabetic by five low doses of streptozotocin. We observed that, in the absence of diabetes, PPARα deficiency resulted in an increase in abortion rate, i.e. 0% in WT mice vs. 20% in PPARα-null mice [odds ratio (OR) = 14.33; P = 0.013]. Under diabetic conditions, the abortion rate was enhanced, i.e. 8.3% in WT mice vs. 50% in PPARα-null mice (OR = 4.28; P = 0.011). In the pups born to diabetic dams, the offspring mortality, due to the absence of PPARα, was enhanced, i.e. 27.7% in WT mice vs. 78.9% in PPARα-null animals (OR = 11.48; P < 0.001). Moreover, we observed that T helper (Th) 1/Th2 balance was shifted to a pregnancy protecting Th2 phenotype in WT diabetic dams and to a noxious Th1 phenotype in PPARα-null mice with diabetic pregnancy. Furthermore, offspring born to diabetic WT dams were hyperinsulinemic and hyperglycemic, and they exhibited upregulated profile of Th2 cytokines, whereas those born to diabetic PPARα-null dams were hypoinsulinemic and hyperglycemic, and they showed down-regulated profile of Th2 cytokines. However, IFN-γ, a Th1 cytokine, was up-regulated in the offspring of both diabetic WT and PPARα-null dams. Altogether, our results suggest that PPARα deficiency in mice may be implicated in the increase in maternal abortion, neonatal mortality, and T cell differentiation. Copyright © 2006 by The Endocrine Society.
Authors & Co-Authors
Yessoufou, Akadiri
France, Dijon
Université de Bourgogne
Benin, Cotonou
University of Abomey-calavi
Hichami, Aziz
France, Dijon
Université de Bourgogne
Besnard, Philippe
France, Dijon
L'institut Agro Dijon
Moutairou, Kabirou A.
France, Dijon
Université de Bourgogne
Khan, Naim Akhtar
France, Dijon
Université de Bourgogne
Statistics
Citations: 58
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1210/en.2006-0067
ISSN:
00137227
e-ISSN:
00137227
Research Areas
Genetics And Genomics
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Case-Control Study