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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion
Malaria Journal, Volume 18, No. 1, Article 20, Year 2019
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Description
Background: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. Methods: Blood samples were collected in the five countries during National Malaria Surveys or during Population Surveys. During Population Surveys samples were characterized for G6PD phenotype using the Fluorescent Spot Test. Samples were then genotyped for a panel of G6PD mutations. Results: G6PD deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in Thailand, 8.1% in Lao PDR, 8.9% in Vietnam, 15.8% in Myanmar and 18.8% in Cambodia. Mahidol and Viangchan mutations were the most common and widespread variants found among the nine investigated. Conclusions: Owing to the high prevalence of G6PD deficiency in the Greater Mekong Subregion, strategies for vivax malaria elimination should include point-of-care G6PD testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines. © 2019 The Author(s).
Authors & Co-Authors
Bancone, Germana
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Menard, Didier
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
France, Paris
Institut Pasteur, Paris
Khim, Nimol
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Kim, Saorin
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Canier, Lydie
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Phommasone, Koukeo
Thailand
Mahosot Hospital, Lao
Mayxay, Mayfong
United Kingdom, Oxford
University of Oxford
Thailand
Mahosot Hospital, Lao
Laos, Vientiane
University of Health Sciences
Dittrich, Sabine
United Kingdom, Oxford
University of Oxford
Thailand
Mahosot Hospital, Lao
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Fievét, Nadine
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Le-Hesran, Jean Yves
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Briand, Valérie
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Keomany, Sommay
Unknown Affiliation
Newton, Paul N.
United Kingdom, Oxford
University of Oxford
Thailand
Mahosot Hospital, Lao
Chu, Cindy S.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Dong, Lethanh
Unknown Affiliation
Quang, Huynh Hong
Unknown Affiliation
Thuy-Nhien, Nguyen Thanh
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Hien, Tran Tinh
United Kingdom, Oxford
University of Oxford
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Kalnoky, Michael
United States, Seattle
Path
Nosten, François Henry
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 30
Authors: 20
Affiliations: 10
Identifiers
Doi:
10.1186/s12936-019-2652-y
ISSN:
14752875
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Qualitative
Quantitative