Purpose Botswana, a country with a high prevalence of HIV, has an increasing incidence of cancerrelated mortality in the post-antiretroviral therapy era. Despite universal access to free health care, the majority of Botswana patients with cancer present at advanced stages. This study was designed to explore the factors related to advanced-stage cancer presentation in Botswana. Methods Patients attending an oncology clinic between December 2015 and January 2017 at Princess Marina Hospital in Gaborone, Botswana, completed a questionnaire on sociodemographic and clinical factors as well as cancer-related fears, attitudes, beliefs, and stigma. Odds ratios (ORs) were calculated to identify factors signifcantly associated with advanced stage (stage III and IV) at diagnosis. Results Of 214 patients, 18.7% were men and 81.3% were women. The median age at diagnosis was 46 years, with 71.9% of patients older than 40 years. The most commonly represented cancers included cervical (42.3%), breast (16%), and head and neck (15.5%). Cancer stages represented in the study group included 8.4% at stage I, 19.2% at stage II, 24.1% at stage III, 11.9% at stage IV, and 36.4% at an unknown stage. Patients who presented at advanced stages were signifcantly more likely to not be afraid of having cancer (OR, 3.48; P <.05), believe that their family would not care for them if they needed treatment (OR, 6.35; P =.05), and believe that they could not afford to develop cancer (OR, 2.73; P <.05). The perception that symptoms were less serious was also signifcantly related to advanced stage (P <.05). Patients with non-femalespecifc cancers were more likely to present in advanced stages (OR, 5.67; P <.05). Conclusion Future cancer mortality reduction efforts should emphasize cancer symptom awareness and early detection through routine cancer screening, as well as increasing the acceptability of care-seeking, especially among male patients.
