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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An experimental study on rat myocardium, testicles and urinary bladder
Food and Chemical Toxicology, Volume 48, No. 8-9, Year 2010
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Description
The present study aimed to evaluate the role of DL-alpha-lipoic acid (LA) and squalene (SQ) on oxidative cardiac, testicular and urotoxic damage induced by cyclophosphamide (CP). Male Wistar rats were divided into four groups; three groups received a single intraperitoneal injection of CP (200mg/kg BW) to induce toxicity, and two of these groups received either LA (35mg/kg BW) or SQ (0.4ml/rat) orally 7days before and 7days after CP injection. A vehicle-treated control group was also included. Oxidative damage was observed by decreased serum total antioxidant capacity (TAC) level and abnormal alterations in glutathione peroxidase (GPx) and glutathione reductase (GR) activities, levels of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) and calcium (Ca+2) in the heart, testes and urinary bladder of CP-administered rats. Cardiac marker enzyme activities; creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and aspartate transaminase (AST) showed severe declines whereas testicular markers; sorbitol dehydrogenase (SDH), γ-glutamyl transferase (γ-GT), acid and alkaline phosphatases (ACP and ALP), serum testosterone (T) level and haemoglobin (Hb) absorbance were abnormal. Histopathological observations were also altered. These CP-induced pathological alterations were attenuated by treatment with LA or SQ. These findings highlight the efficacy of LA and SQ as cytoprotectants in CP-induced toxicity. © 2010 Elsevier Ltd.
Authors & Co-Authors
Motawi, T. K.
Egypt, Cairo
Faculty of Pharmacy
Sadik, Nermin Abdel Hamid
Egypt, Cairo
Faculty of Pharmacy
Refaat, Ayat
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 126
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/j.fct.2010.05.067
ISSN:
02786915
Research Areas
Noncommunicable Diseases
Violence And Injury
Study Design
Randomised Control Trial
Participants Gender
Male