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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study
Clinical Microbiology and Infection, Volume 19, No. 5, Year 2013
Notification
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Description
Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Guglielmini, Julien
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Steer, Andrew C.
Australia, Melbourne
Royal Children's Hospital, Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Carapetis, Jonathan Rhys
Australia, Perth
The University of Western Australia
Smeesters, Pierre R.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Belgium, Brussels
Université Libre de Bruxelles
Australia, Melbourne
Murdoch Children's Research Institute
Towers, Rebecca J.
Unknown Affiliation
Goossens, Herman J.
Unknown Affiliation
Malhotra-Kumar, Surbhi
Unknown Affiliation
Low, Donald E.
Unknown Affiliation
Mcgeer, Allison J.
Unknown Affiliation
Křížová, Pavla
Unknown Affiliation
el-Tayeb, Sawsan H.M.
Unknown Affiliation
Kado, Joseph H.
Unknown Affiliation
van der Linden, Mark P.G.
Unknown Affiliation
Watanabe, Haruo
Unknown Affiliation
Sow, Samba Ousmane
Unknown Affiliation
Tamboura, Boubou
Unknown Affiliation
Melo-Cristino, J. A.G.
Unknown Affiliation
Engel, Mark E.
Unknown Affiliation
Mayosi, Bongani M.
Unknown Affiliation
Whitelaw, Andrew C.
Unknown Affiliation
Darenberg, Jessica
Unknown Affiliation
Henriques-Normark, Brigitta
Unknown Affiliation
Efstratiou, Androulla
Unknown Affiliation
Statistics
Citations: 116
Authors: 23
Affiliations: 8
Identifiers
Doi:
10.1111/1469-0691.12134
ISSN:
1198743X
Research Areas
Genetics And Genomics