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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fatigability disrupts cognitive processes' regulation of inflammatory reactivity in old age
American Journal of Geriatric Psychiatry, Volume 22, No. 12, Year 2014
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Description
Objective High fatigability, a dysfunctional adaption to fatigue, may lead to difficulties performing otherwise regularly encountered cognitive activities and may be related to pro-inflammatory reactivity. The purpose of the study was to investigate the effect of fatigability on cognitive processes and inflammatory response after an acute cognitive stress task in older adults. Methods In an observational stress reactivity study conducted in a light-and temperature-controlled laboratory, we measured IL-6, self-reported acute fatigue, and frontally oriented cognitive processes in 55 community-dwelling individuals aged 75 years or older as part of a demanding set of cognitive tasks intended to induce stress. Results Subjects were classified into groups of low and high fatigability based on cluster analysis of their self-report acute fatigue before and after the cognitive tasks. The two clusters were comparable on levels of baseline IL-6 and cognitive processes; however, the high fatigability cluster had significantly higher levels of IL-6 response than the low fatigability cluster. After controlling for multiple covariates, fatigability moderated the relationship between speed of processing and IL-6 reactivity. Further exploratory analyses indicated significant adverse associations between speed of processing and attention and IL-6 reactivity in the group with low but not high fatigability. Conclusion Although observational, these data are consistent with the notion that pro-inflammatory states in older adults might be reduced by improvements in cognitive processes. Because fatigability was associated with increased acute inflammatory response and disrupted the normal stress regulation provided by the cognitive processes, future randomized studies might examine whether fatigability alleviation reduces IL-6. © 2014 American Association for Geriatric Psychiatry.
Authors & Co-Authors
Chapman, Benjamin P.
Unknown Affiliation
Brasch, Judith D.
United States, Rochester
University of Rochester School of Nursing
Chen, Ding Geng(Din)
United States, Rochester
University of Rochester School of Nursing
United States, Boston
Departments of Biostatistics and Computational Biology
Statistics
Citations: 7
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.jagp.2013.12.003
ISSN:
10647481
Study Design
Exploratory Study