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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus
Cell Reports, Volume 42, No. 11, Article 113366, Year 2023
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Description
Monoclonal antibodies against the Ebola virus (EBOV) surface glycoprotein are effective treatments for EBOV disease. Antibodies targeting the EBOV glycoprotein (GP) head epitope have potent neutralization and Fc effector function activity and thus are of high interest as therapeutics and for vaccine design. Here we focus on the head-binding antibodies 1A2 and 1D5, which have been identified previously in a longitudinal study of survivors of EBOV infection. 1A2 and 1D5 have the same heavy- and light-chain germlines despite being isolated from different individuals and at different time points after recovery from infection. Cryoelectron microscopy analysis of each antibody in complex with the EBOV surface GP reveals key amino acid substitutions in 1A2 that contribute to greater affinity, improved neutralization potency, and enhanced breadth as well as two strategies for antibody evolution from a common site. © 2023 The Authors
Authors & Co-Authors
Hastie, Kathryn M.
Unknown Affiliation
Hui, Sean
Unknown Affiliation
Mann, Colin J.
Unknown Affiliation
Takada, Ayato
Japan, Sapporo
Hokkaido University
Ahmed, Rafi
United States, Atlanta
Emory University
Saphire, Erica Ollmann
United States, La Jolla
University of California, San Diego
Statistics
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.celrep.2023.113366
ISSN:
22111247
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative