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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d'Ivoire
Journal of Ethnopharmacology, Volume 90, No. 2-3, Year 2004
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Description
The antitrypanosomal activity of 101 crude ethanol extracts derived from 88 medicinal plants from Côte d'Ivoire was determined in vitro using Trypanosoma brucei rhodesiense. Of those extracts 8 showed good activity (IC50 values ≤8μg/ml), 37 revealed a weak activity (IC 50 values between 25 and 8.1μg/ml) and 56 did not show any activity at all (IC50 values >25μg/ml). The extracts of Enantia polycarpa (Annonaceae) and Trichilia emetica (Meliaceae) were the most promising ones. Their IC50 values were 0.5 and 0.04μg/ml, respectively, and the selectivity index 616 and 209, respectively. This is the first report of in vitro antitrypanosomal activity of these two plants. Their high activities render them candidates for the isolation of compounds which could develop into new lead structures for drug development programs against African trypanosomiasis. Seven of the tested extracts exhibited an antiplasmodial activity against K1 strain of Plasmodium falciparum with IC 50 values below 4μg/ml. The highest activity was found for Enantia polycarpa stem bark with an IC50 value of 0.126μg/ml. © 2003 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Kamanzi Atindehou, K.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherche Scientifique en Côte D’ivoire
Schmid, Cécile
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Brun, Reto
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Koné, Mariatou W.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherche Scientifique en Côte D’ivoire
Traoré, Dossahoua Kapitché
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Statistics
Citations: 192
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2003.09.032
ISSN:
03788741
Study Locations
Ivory Coast