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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Modulation of adipokines and cytokines in gestational diabetes and macrosomia
Journal of Clinical Endocrinology and Metabolism, Volume 91, No. 10, Year 2006
Notification
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Description
Context/Objective: Not much is known about the implication of adipokines and different cytokines in gestational diabetes mellitus (GDM) and macrosomia. The purpose of this study was to assess the profile of these hormones and cytokines in macrosomic babies, born to gestational diabetic women. Design/Subjects: A total of 59 women (age, 19-42 yr) suffering from GDM with their macrosomic babies (4.35 ± 0.06 kg) and 60 healthy age-matched pregnant women and their newborns (3.22 ± 0.08 kg) were selected. Methods: Serum adipokines (adiponectin and leptin) were quantified using an obesity-related multiple ELISA microarray kit. The concentrations of serum cytokines were determined by ELISA. Results: Serum adiponectin levels were decreased, whereas the concentrations of leptin, inflammatory cytokines, such as IL-6 and TNF-α, were significantly increased in gestational diabetic mothers compared with control women. The levels of these adipocytokines were diminished in macrosomic babies in comparison with their age-matched control newborns. Serum concentrations of T helper type 1 (Th1) cytokines (IL-2 and interferon-γ) were decreased, whereas IL-10 levels were significantly enhanced in gestational diabetic mothers compared with control women. Macrosomic children exhibited high levels of Th1 cytokines and low levels of IL-10 compared with control infants. Serum IL-4 levels were not altered between gestational diabetic mothers and control mothers or the macrosomic babies and newborn control babies. Conclusions: GDM is linked to the down-regulation of adiponectin along with Th1 cytokines and up-regulation of leptin and inflammatory cytokines. Macrosomia was associated with the up-regulation of Th1 cytokines and the down-regulation of the obesity-related agents (IL-6 and TNF-α, leptin, and adiponectin). Copyright © 2006 by The Endocrine Society.
Authors & Co-Authors
Atègbo, Jean Marc
France, Dijon
Université de Bourgogne
Benin, Cotonou
University of Abomey-calavi
Grissa, Oussama
Tunisia, Sousse
Hopital Farhat Hached Sousse
Yessoufou, Akadiri
France, Dijon
Université de Bourgogne
Benin, Cotonou
University of Abomey-calavi
Hichami, Aziz
France, Dijon
Université de Bourgogne
Dramane, Karim L.
Benin, Cotonou
University of Abomey-calavi
Moutairou, Kabirou A.
Benin, Cotonou
University of Abomey-calavi
Miled, Abdelhédi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Grissa, Abir K.
Tunisia, Sousse
Hopital Farhat Hached Sousse
Jerbi, Mehdi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Tabka, Zouhaïr
Tunisia, Sousse
Hopital Farhat Hached Sousse
Khan, Naim Akhtar
France, Dijon
Université de Bourgogne
Statistics
Citations: 374
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1210/jc.2006-0980
ISSN:
0021972X
e-ISSN:
0021972X
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Participants Gender
Female