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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8
+
T cell response
Journal of Immunology, Volume 177, No. 8, Year 2006
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Description
Mounting evidence points to CD8+ T cells playing an important role in protective immunity against Mycobacterium tuberculosis. The only available vaccine against tuberculosis, bacillus Calmette Guérin (BCG), has traditionally been viewed not to induce these cells optimally. In this study, we show that vaccination of human newborns with BCG does indeed induce a specific CD8+ T cell response. These cells degranulated or secreted IFN-γ, but not both, when infant blood was incubated with BCG. This stimulation also resulted in proliferation and up-regulation of cytotoxic molecules. Overall, the specific CD8+ T cell response was quantitatively smaller than the BCG-indnced CD4+ T cell response. Incubation of whole blood with M. tuberculosis also caused CD8+ T cell IFN-γ expression. We conclude that BCG induces a robust CD8 + T cell response, which may contribute to vaccination-induced protection against tuberculosis. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Murray, Rose Ann
United States, Newark
Public Health Research Institute
Mansoor, Nazma
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Harbacheuski, Ryhor
United States, Newark
Public Health Research Institute
Soler, Jorge H.
United States, Newark
Public Health Research Institute
Davids, Virginia
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Soares, Andreia P.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hawkridge, Anthony J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Maecker, Holden Terry
United States, San Jose
Bd Biosciences
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Statistics
Citations: 77
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.177.8.5647
ISSN:
00221767
Research Areas
Maternal And Child Health