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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
In vitro activity of ferroquine (SAR97193) is independent of chloroquine resistance in Plasmodium falciparum
American Journal of Tropical Medicine and Hygiene, Volume 75, No. 6, Year 2006
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Description
Nowadays, chloroquine-resistant malaria appears in almost all endemic regions. Ferroquine is a derivative of chloroquine and shows good activity in vitro and in animal models, but the development of cross-resistance is of concern. We tested in vitro susceptibilities of Plasmodium falciparum field isolates from Gabon to ferroquine, chloroquine, and artesunate. As expected, chloroquine resistance was present in all parasite isolates (median 50% inhibitory concentration = 113 nmol/L). Ferroquine (1.94 nmol/L) and artesunate (0.96 nmol/L) were highly active, and no significant correlation between any of the three drugs was observed. In contrast to our findings, previous studies showed an association between chloroquine and ferroquine activities. We could reproduce this association by using different initial parasitemias, but analysis of covariance revealed that initial parasitemia and not parasite strain was the critical determinant for the correlation between chloroquine and ferroquine activities. We conclude that ferroquine is highly active in chloroquine- resistant parasites, and we anticipate no enhanced selection for resistance against ferroquine in chloroquine-resistant parasites. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Kreidenweiss, Andrea
Gabon, Lambarene
Hôpital Albert Schweitzer
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Gabon, Lambarene
Hôpital Albert Schweitzer
Germany, Tubingen
Eberhard Karls Universität Tübingen
Dietz, Klaus
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mordmüller, Benjamin G.
Gabon, Lambarene
Hôpital Albert Schweitzer
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 56
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.2006.75.1178
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Gabon