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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Protective effect of resveratrol in endotoxemia-induced acute phase response in rats
Archives of Toxicology, Volume 83, No. 4, Year 2009
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Description
Lipopolysaccharide (LPS), a glycolipid component of the cell wall of gram-negative bacteria can elicit a systemic inflammatory process leading to septic shock and death. Acute phase response is characterized by fever, leucocytosis, thrombocytopenia, altered metabolic responses and redox balance by inducing excessive reactive oxygen species (ROS) generation. Resveratrol (trans-3,5,4̀ trihydroxystilbene) is a natural polyphenol exhibiting antioxidant and anti-inflammatory properties. We investigated the protective effect of resveratrol on endotoxemia-induced acute phase response in rats. When acutely administered by i.p. route, resveratrol (40 mg/kg b.w.) counteracted the effect of a single injection of LPS (4 mg/kg b.w.) which induced fever, a decrease in white blood cells (WBC) and platelets (PLT) counts. When i.p. administered during 7 days at 20 mg/kg per day (subacute treatment), resveratrol abrogated LPS-induced erythrocytes lipoperoxidation and catalase (CAT) activity depression to control levels. In the plasma compartment, LPS increased malondialdehyde (MDA) via nitric monoxide (NO) elevation and decreased iron level. All these deleterious LPS effects were reversed by a subacute resveratrol pre-treatment via a NO independent way. Resveratrol exhibited potent protective effect on LPS-induced acute phase response in rats. © 2008 Springer-Verlag.
Authors & Co-Authors
Sebaí, Hichem
Tunisia, Tunis
University of Carthage
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Ben Attia, M.
Tunisia, Tunis
University of Carthage
Sani, Mamane
Tunisia, Tunis
University of Carthage
Aouani, Ezzedine
Tunisia, Tunis
University of Carthage
Ghanem-Boughanmi, Néziha
Tunisia, Tunis
University of Carthage
Statistics
Citations: 57
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1007/s00204-008-0348-0
ISSN:
03405761
Research Areas
Mental Health
Noncommunicable Diseases