Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CAA insertion polymorphism in the 3′UTR of Nogo gene on 2p14 is not associated with schizophrenia
Molecular Brain Research, Volume 133, No. 1, Year 2005
Notification
URL copied to clipboard!
Description
The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data. In this study, we attempt to replicate the possible association of the CAA insertion and a nearby TATC deletion with schizophrenia in 204 complete and incomplete triads and in a sample of 462 unrelated cases and 153 controls, all of Caucasian origin. Our genotyping results indicated that neither the trinucleotide insertion polymorphism (CAAins; 43.4% vs. 41.8%, p>0.5) nor the polymorphism-TATC deletion (TATCdel; 49.8% vs. 49.3%, p>0.1) allele frequency is significantly different in patients compared to controls. The homozygous CAAins frequency is not significantly different between patients and controls either (18.0% vs. 15.0%, χ2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring. © 2004 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Xiong, Lan
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
Rouleau, Guy Armand
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
DeLisi, Lynn Eleanor
United States, Albany
State University of new York System
St.-Onge, Judith
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
Najafee, Robert
Canada, Montreal
Le Centre de Recherche Douglas
Rivière, Jean Baptiste
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
Benkelfat, Chawki
Canada, Montreal
Le Centre de Recherche Douglas
Tabbane, Karim
Tunisia, Tunis
Université de Tunis
Fathalli, Ferid
Canada, Montreal
Le Centre de Recherche Douglas
Danics, Zoltán
Hungary, Budapest
National Institute of Mental Health
Labelle, Alain
Canada, Ottawa
University of Ottawa
Lal, Samarthji
Canada, Montreal
Le Centre de Recherche Douglas
Joober, Ridha
Canada, Montreal
Le Centre de Recherche Douglas
Statistics
Citations: 13
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1016/j.molbrainres.2004.08.024
ISSN:
0169328X
Research Areas
Genetics And Genomics
Mental Health