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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
The role of leptin levels in adaptation to cold climates
International Journal of Environmental Research and Public Health, Volume 17, No. 6, Article 1854, Year 2020
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Description
Currently, adipose tissue is considered an endocrine organ that produces hormone-active substances, including leptin, which can play a key role in thermoregulation processes. Therefore, we performed a meta-analysis to investigate the influence of the climatic environment on leptin levels. A systematic literature search in the databases was carried out on 10 January 2020. Finally, 22 eligible articles were included in the current meta-analysis and a total of 13,320 participants were covered in the final analysis. It was shown that males of the “North” subgroup demonstrated significantly higher levels of leptin (10.02 ng/mL; CI: 7.92–12.13) than males of the “South” subgroup (4.9 ng/mL; CI: 3.71–6.25) (p = 0.0001). On the contrary, in the female group, a similar pattern was not detected (p = 0.91). Apparently, in order to maintain body temperature, higher leptin levels are required. The results of the study indicate that such effects are most pronounced in males and to a smaller extent in females, apparently due to a relatively high initial concentration of leptin in females. The correlation between leptin levels and climatic environment data support the hypothesis of leptin-mediated thermoregulation as an adaptive mechanism to cold climates. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Barashkov, N. A.
Russian Federation, Yakutsk
Yakut Science Centre of Complex Medical Problems sb Rams
Russian Federation, Yakutsk
North-eastern Federal University
Odland, Jon Øyvind
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Fedorova, Sardana A.
Russian Federation, Yakutsk
Yakut Science Centre of Complex Medical Problems sb Rams
Russian Federation, Yakutsk
North-eastern Federal University
Statistics
Citations: 5
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.3390/ijerph17061854
ISSN:
16617827
Research Areas
Environmental
Study Approach
Systematic review
Participants Gender
Female