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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Establishment of the first International Repository for Transfusion-Relevant Bacteria Reference Strains: ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria
Vox Sanguinis, Volume 102, No. 1, Year 2012
Notification
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Description
Background Bacterial contamination of platelet concentrates (PCs) still remains a significant problem in transfusion with potential important clinical consequences, including death. The International Society of Blood Transfusion Working Party on Transfusion-Transmitted Infectious Diseases, Subgroup on Bacteria, organised an international study on Transfusion-Relevant Bacteria References to be used as a tool for development, validation and comparison of both bacterial screening and pathogen reduction methods. Material and Methods Four Bacteria References (Staphylococcus epidermidis PEI-B-06, Streptococcus pyogenes PEI-B-20, Klebsiella pneumoniae PEI-B-08 and Escherichia coli PEI-B-19) were selected regarding their ability to proliferate to high counts in PCs and distributed anonymised to 14 laboratories in 10 countries for identification, enumeration and bacterial proliferation in PCs after low spiking (0·3 and 0·03CFU/ml), to simulate contamination occurring during blood donation. Results Bacteria References were correctly identified in 98% of all 52 identifications. S. pyogenes and E. coli grew in PCs in 11 out of 12 laboratories, and K. pneumoniae and S. epidermidis replicated in all participating laboratories. The results of bacterial counts were very consistent between laboratories: the 95% confidence intervals were for S. epidermidis: 1·19-1·32×107CFU/ml, S. pyogenes: 0·58-0·69 ×107CFU/ml, K. pneumoniae: 18·71-20·26×107CFU/ml and E. coli: 1·78-2·10×107CFU/ml. Conclusion The study was undertaken as a proof of principle with the aim to demonstrate (i) the quality, stability and suitability of the bacterial strains for low-titre spiking of blood components, (ii) the property of donor-independent proliferation in PCs, and (iii) their suitability for worldwide shipping of deep frozen, blinded pathogenic bacteria. These aims were successfully fulfilled. The WHO Expert Committee Biological Standardisation has approved the adoption of these four bacteria strains as the first Repository for Transfusion-Relevant Bacteria Reference Strains and, additionally, endorsed as a project the addition of six further bacteria strain preparations suitable for control of platelet contamination as the next step of enlargement of the repository. © 2011 The Author(s). Vox Sanguinis © 2011 International Society of Blood Transfusion.
Authors & Co-Authors
Störmer, M.
Germany, Langen
Paul-ehrlich-institut
Arroyo, A.
Mexico, Mexico City
Centro Nacional de la Transfusión Sanguínea
Brachert, J.
Germany, Langen
Paul-ehrlich-institut
Carrero, H.
United States, Bethesda
Walter Reed National Military Medical Center
Devine, Dana V.
Canada, Ottawa
Canadian Blood Service
Epstein, J. S.
United States, Silver Spring
Food and Drug Administration
Gabriel, Christian
Unknown Affiliation
Gelber, C.
United States, Manassas
American Type Culture Collection
Goodrich, Raymond P.
United States, Lakewood
Caridianbct Biotechnologies
Hanschmann, Kay Martin
Germany, Langen
Paul-ehrlich-institut
Heath, D. G.
United States, Bethesda
Walter Reed National Military Medical Center
Jacobs, Michael R.
United States, Cleveland
Case Western Reserve University
Keil, S. D.
United States, Lakewood
Caridianbct Biotechnologies
de Korte, Dirk J.
Netherlands, Amsterdam
Stichting Sanquin Bloedvoorziening
Lambrecht, B.
Germany, Berlin
Deutsches Rotes Kreuz
Lee, Cheuk Kwong
China, Hong Kong
Hong Kong Red Cross Blood Transfusion Service
Marcelis, Jan H.
Netherlands, Amsterdam
Stichting Sanquin Bloedvoorziening
Marschner, S.
United States, Lakewood
Caridianbct Biotechnologies
McDonald, C. P.
United Kingdom, Bristol
Nhs Blood and Transplant
McGuane, S.
United Kingdom, Bristol
Nhs Blood and Transplant
McKee, M.
United States, Manassas
American Type Culture Collection
Müller, T. H.
Germany, Berlin
Deutsches Rotes Kreuz
Muthivhi, Tshilidzi N.
South Africa, Weltevreden Park
South African National Blood Service
Pettersson, Annika M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Radziwon, P.
Poland, Bialystok
Regional Centre for Transfusion Medicine
Ramírez-Arcos, Sandra M.
Canada, Ottawa
Canadian Blood Service
Reésink, Hendrick W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Rojo, J.
Mexico, Mexico City
Centro Nacional de la Transfusión Sanguínea
Rood, I.
Netherlands, Amsterdam
Stichting Sanquin Bloedvoorziening
Schmidt, Michael
Germany, Berlin
Deutsches Rotes Kreuz
Schneider, C. K.
Germany, Langen
Paul-ehrlich-institut
Seifried, Erhard
Germany, Berlin
Deutsches Rotes Kreuz
Sicker, U.
Germany, Langen
Paul-ehrlich-institut
Wendel, Silvano N.
Brazil, Bela Vista
Hospital Sirio-libanês
Wood, Erica M.
Australia, Melbourne
Australian Red Cross Blood Service
Yomtovian, R.
United States, Cleveland
Louis Stokes Cleveland va Medical Center
Montag, T.
Germany, Langen
Paul-ehrlich-institut
Statistics
Citations: 46
Authors: 37
Affiliations: 19
Identifiers
Doi:
10.1111/j.1423-0410.2011.01510.x
ISSN:
00429007