Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The RAST Server: Rapid annotations using subsystems technology
BMC Genomics, Volume 9, Article 75, Year 2008
Notification
URL copied to clipboard!
Description
Background: The number of prokaryotic genome sequences becoming available is growing steadily and is growing faster than our ability to accurately annotate them. Description: We describe a fully automated service for annotating bacterial and archaeal genomes. The service identifies protein-encoding, rRNA and tRNA genes, assigns functions to the genes, predicts which subsystems are represented in the genome, uses this information to reconstruct the metabolic network and makes the output easily downloadable for the user. In addition, the annotated genome can be browsed in an environment that supports comparative analysis with the annotated genomes maintained in the SEED environment. The service normally makes the annotated genome available within 12-24 hours of submission, but ultimately the quality of such a service will be judged in terms of accuracy, consistency, and completeness of the produced annotations. We summarize our attempts to address these issues and discuss plans for incrementally enhancing the service. Conclusion: By providing accurate, rapid annotation freely to the community we have created an important community resource. The service has now been utilized by over 120 external users annotating over 350 distinct genomes. © 2008 Aziz et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Aziz, Ramy Karam
United States, Memphis
University of Tennessee Health Science Center
Egypt, Cairo
Faculty of Pharmacy
Bartels, Daniela
United States, Chicago
The University of Chicago
Best, Aaron
United States, Holland
Hope College
DeJongh, Matthew
United States, Holland
Hope College
Disz, Terry
United States, Lemont
Argonne National Laboratory
United States, Chicago
The University of Chicago
Edwards, Robert A.
United States, Burr Ridge
Fellowship for Interpretation of Genomes
United States, Lemont
Argonne National Laboratory
Formsma, Kevin
United States, Holland
Hope College
Gerdes, Svetlana
United States, Burr Ridge
Fellowship for Interpretation of Genomes
Glass, Elizabeth M.
United States, Lemont
Argonne National Laboratory
Kubal, Michael
United States, Chicago
The University of Chicago
Meyer, Folker
United States, Lemont
Argonne National Laboratory
United States, Chicago
The University of Chicago
Olsen, Gary J.
United States, Lemont
Argonne National Laboratory
United States, Urbana
University of Illinois Urbana-champaign
Olson, Robert
United States, Lemont
Argonne National Laboratory
United States, Chicago
The University of Chicago
Osterman, Andrei L.
United States, Burr Ridge
Fellowship for Interpretation of Genomes
United States, San Diego
Sanford Burnham Prebys Medical Discovery Institute
Overbeek, Ross A.
United States, Burr Ridge
Fellowship for Interpretation of Genomes
McNeil, Leslie Klis
United States, Urbana
University of Illinois Urbana-champaign
Paarmann, Daniel
United States, Chicago
The University of Chicago
Paczian, Tobias
United States, Chicago
The University of Chicago
Parrello, Bruce
United States, Burr Ridge
Fellowship for Interpretation of Genomes
Pusch, Gordon D.
United States, Burr Ridge
Fellowship for Interpretation of Genomes
United States, Chicago
The University of Chicago
Reich, Claudia
United States, Urbana
University of Illinois Urbana-champaign
Stevens, Rick L.
United States, Lemont
Argonne National Laboratory
United States, Chicago
The University of Chicago
Vassieva, Olga
United States, Burr Ridge
Fellowship for Interpretation of Genomes
Vonstein, Veronika
United States, Burr Ridge
Fellowship for Interpretation of Genomes
Wilke, Andreas
United States, Chicago
The University of Chicago
Zagnitko, Olga
United States, Burr Ridge
Fellowship for Interpretation of Genomes
Statistics
Citations: 9,822
Authors: 26
Affiliations: 8
Identifiers
Doi:
10.1186/1471-2164-9-75
e-ISSN:
14712164
Research Areas
Noncommunicable Diseases