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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical features and outcome of severe malaria in gambian children
Clinical Infectious Diseases, Volume 21, No. 3, Year 1995
Notification
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Description
The clinical and laboratory features of severe falciparum malaria in 180 Gambian children were studied between 1985 and 1989. Of the 180 children, 118 (66%) presented with seizures, 77 (43%) had cerebral malaria, 35 (20%) had witnessed seizures after admission, 29 (16%) were hypoglycemic, and 27 (15%) died. Respiratory distress was a common harbinger of a fatal outcome. The differences in admission parasite counts in the blood, hematocrit, and opening cerebrospinal pressures for patients who died and survivors were not significant. A multiple logistic regression model identified neurological status (coma, particularly if associated with extensor posturing), stage of parasite development on the peripheral blood film, pulse rate of >150 or respiratory rate of >50, hypoglycemia, and hyperlactatemia (plasma lactate level, >5 mmol/L) as independent indicators of a fatal outcome. Biochemical evidence of hepatic and renal dysfunction was an additional marker of a poor prognosis, but, in contrast to severe malaria in adults, none of these children with severe malaria had acute renal failure. © 1995 by The University of Chicago. All rights reserved.
Authors & Co-Authors
Waller, Deborah J.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Krishna, Prof Sanjeev
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Crawley, Jane C.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Miller, Kirk D.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Nosten, François Henry
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Chapman, D.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
ter Kuile, Feiko O.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Craddock, Charles F.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Berry, Carol Dawn
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Holloway, Paul A.H.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Brewster, David R.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Greenwood, Brian M.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
White, Nicholas J.
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Atlanta
Centers for Disease Control and Prevention
United States, Seattle
University of Washington
Thailand, Nakhon Pathom
Mahidol University
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 223
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1093/clinids/21.3.577
ISSN:
10584838
Research Areas
Infectious Diseases
Maternal And Child Health