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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?
Psychiatry Research, Volume 188, No. 1, Year 2011
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Description
We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood disorders compared with control individuals. Hence we evaluated TL as a possible mediator of the observed association between consanguinity and BP1/SZ risk. Patients with BP1 (n = 108), or SZ (n = 60) were compared with screened adult controls in separate experiments. TL was estimated using a quantitative PCR (qPCR) based assay. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ('DNA-based' rate); and from family history data ('self report'). Significant correlation between TL and DNA based inbreeding was not observed overall, though suggestive trends were present among the SZ cases. No significant case-control differences in TL were found after controlling for demographic variables. In conclusion, reduced TL may not explain a significant proportion of observed associations between consanguinity and risk for BP1/SZ. © 2011 Elsevier Ltd.
Authors & Co-Authors
Mansour, Hader A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Egypt, Mansoura
Faculty of Medicine
Chowdari, Kodavali Venkat
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Fathi, Warda
Egypt, Mansoura
Faculty of Medicine
Elassy, Mai
Egypt, Mansoura
Faculty of Medicine
Ibrahim, Ibtihal Mohamed Aly
Egypt, Mansoura
Faculty of Medicine
Wood, Joel A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Bamne, Mikhil N.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Tobar, Salwa Salah
Egypt, Mansoura
Faculty of Medicine
Yassin, Amal
Egypt, Mansoura
Faculty of Medicine
Salah, Hala
Egypt, Mansoura
Faculty of Medicine
Elsayed, Hanan
Egypt, Mansoura
Faculty of Medicine
Eissa, Ahmed Ibrahim
Egypt, Mansoura
Faculty of Medicine
El-Boraie, Hala Ahmed
Egypt, Mansoura
Faculty of Medicine
Ibrahim, Nahed E.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Elsayed, Mohamed Abd Elaziz
Egypt, Mansoura
Faculty of Medicine
El-Bahaei, Wafaa
Egypt, Mansoura
Faculty of Medicine
Gomaa, Zeinab Abo Elfotouh
Egypt, Mansoura
Faculty of Medicine
El-Chennawi, Farha Abdel Aziz
Egypt, Mansoura
Faculty of Medicine
Nimgaonkar, Vishwajit Laxmikant
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Statistics
Citations: 54
Authors: 19
Affiliations: 3
Identifiers
Doi:
10.1016/j.psychres.2011.01.010
ISSN:
01651781
e-ISSN:
01651781
Research Areas
Genetics And Genomics
Mental Health
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Egypt