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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Nature Communications, Volume 6, Article 7138, Year 2015
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Description
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies. © 2015 Macmillan Publishers Limited.
Authors & Co-Authors
Schumacher, Fredrick R.
United States, Los Angeles
University of Southern California
Schmit, Stephanie L.
United States, Los Angeles
University of Southern California
Edlund, Christopher K.
United States, Los Angeles
University of Southern California
Wang, Hansong
United States, Honolulu
University of Hawaiʻi Cancer Center
Hsu, Li
United States, Seattle
Fred Hutchinson Cancer Center
Idos, Gregory E.
United States, Los Angeles
University of Southern California
Lejbkowicz, Flavio
Israel, Haifa
Carmel Medical Center
Israel, Tel Aviv-yafo
Clalit Health Services
Melas, Marilena
United States, Los Angeles
University of Southern California
Thomas, Duncan Campbell
United States, Los Angeles
University of Southern California
van den Berg, David J.
United States, Los Angeles
University of Southern California
Hutter, Carolyn M.
United States, Bethesda
National Institutes of Health Nih
Aragaki, Aaron K.
United States, Seattle
Fred Hutchinson Cancer Center
Caan, Bette J.
United States, Oakland
Kaiser Permanente
Carlson, Christopher S.
United States, Seattle
Fred Hutchinson Cancer Center
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Curtis, Keith R.
United States, Seattle
Fred Hutchinson Cancer Center
Fuchs, Charles Stewart
United States, Boston
Brigham and Women's Hospital
United States, Boston
Dana-farber Cancer Institute
Gala, Manish K.
United States, Boston
Massachusetts General Hospital
Gogarten, Stephanie M.
United States, Seattle
University of Washington
Hayes, Richard B.
United States, New York
New York University
Henderson, Brian E.
United States, Los Angeles
University of Southern California
Hunter, David John
United States, Boston
Harvard T.h. Chan School of Public Health
Jackson, Rebecca D.
United States, Columbus
The Ohio State University
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi at Mānoa
Kooperberg, Charles L.
United States, Seattle
Fred Hutchinson Cancer Center
Küry, Sébastien
France, Nantes
Chu de Nantes
LaCroix, Andrea Z.
United States, Seattle
Fred Hutchinson Cancer Center
Laurie, Cathy C.
United States, Seattle
University of Washington
Laurie, Cecilia A.
United States, Seattle
University of Washington
Lemire, Mathieu
Canada, Toronto
Ontario Institute for Cancer Research
Levine, David M.
United States, Seattle
University of Washington
Ma, Jing
United States, Boston
Harvard T.h. Chan School of Public Health
Qu, Conghui
United States, Seattle
Fred Hutchinson Cancer Center
Ulrich, Cornelia M.
United States, Seattle
Fred Hutchinson Cancer Center
Germany, Heidelberg
German Cancer Research Center
United States, Seattle
University of Washington
West, Dee W.
United States, Oakland
Public Health Institute
Berndt, Sonja I.
United States, Rockville
National Cancer Institute Nci
Bézieau, Stéphane
France, Nantes
Hôtel Dieu Chu de Nantes
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Campbell, Peter T.
United States, Kennesaw
American Cancer Society
Chan, Andrew Tan
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Chang-Claude, Jenny C.
Germany, Heidelberg
German Cancer Research Center
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Conti, David V.
United States, Los Angeles
University of Southern California
Duggan, David J.
United States, Phoenix
Translational Genomics Research Institute
Figueiredo, Jane C.
United States, Los Angeles
University of Southern California
Gallinger, Steven J.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Gauderman, William James
United States, Los Angeles
University of Southern California
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Haile, Robert W.C.
United States, Palo Alto
Stanford University
Harrison, Tabitha A.
United States, Seattle
Fred Hutchinson Cancer Center
Hoffmeister, Michael
Germany, Heidelberg
German Cancer Research Center
Hopper, John Llewelyn
Australia, Melbourne
University of Melbourne
Iwasaki, Motoki
Japan, Tokyo
National Cancer Center Japan
Jee, Sunha
South Korea, Seoul
Yonsei University
Jenkins, Mark Andrew
Australia, Melbourne
University of Melbourne
Joshi, Amit D.
United States, Boston
Harvard T.h. Chan School of Public Health
Li, Li
United States, Cleveland
Case Western Reserve University
Lindor, Noralane M.
United States, Scottsdale
Mayo Clinic Scottsdale-phoenix, Arizona
Matsuo, Keitaro
Japan, Fukuoka
Kyushu University
Moreno, Victor R.
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Newcomb, Polly A.
United States, Seattle
Fred Hutchinson Cancer Center
Potter, John D.
United States, Seattle
Fred Hutchinson Cancer Center
Raskin, Leon
United States, Los Angeles
University of Southern California
United States, Nashville
Vanderbilt University
Rennert, Gad
United States, Los Angeles
University of Southern California
Israel, Haifa
Carmel Medical Center
Israel, Tel Aviv-yafo
Clalit Health Services
Israel, Haifa
Technion - Israel Institute of Technology
Severi, Gianluca
Australia, East Melbourne
Cancer Council Victoria
Italy, Torino
Human Genetics Foundation
Schoen, Robert E.
United States, Pittsburgh
University of Pittsburgh Medical Center
Seminara, Daniela
United States, Bethesda
National Institutes of Health Nih
Shu, Xiaoou
United States, Nashville
Vanderbilt University
Slattery, Martha L.
United States, Salt Lake City
The University of Utah
Tsugane, Shoichiro
Japan, Tokyo
National Cancer Center Japan
Xiang, Yongbing
China, Shanghai
Shanghai Cancer Institute
Zheng, Wei
United States, Nashville
Vanderbilt University
Le Marchand, Loïc
United States, Honolulu
University of Hawaiʻi Cancer Center
Casey, Graham
United States, Los Angeles
University of Southern California
Gruber, Stephen Bernard
United States, Los Angeles
University of Southern California
Peters, Ulrike
United States, Seattle
Fred Hutchinson Cancer Center
Statistics
Citations: 128
Authors: 76
Affiliations: 49
Identifiers
Doi:
10.1038/ncomms8138
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study