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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry
PLoS Genetics, Volume 7, No. 10, Article e1002298, Year 2011
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Description
Adult height is a classic polygenic trait of high heritability (h 2 ~0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ~10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10 -12 and 2p14-rs4315565, P = 1.2×10 -8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10 -4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits. © 2011 N'Diaye et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s005.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3188544/bin/pgen.1002298.s006.doc
Authors & Co-Authors
N’Diaye, Amidou
Unknown Affiliation
Chen, Gary K.
Unknown Affiliation
Palmer, Cameron D.
Unknown Affiliation
Ge, Bing
Unknown Affiliation
Tayo, Bamidele O.
Unknown Affiliation
Mathias, Rasika Ann
Unknown Affiliation
Ding, Jingzhong
Unknown Affiliation
Nalls, Mike A.
Unknown Affiliation
Adeyemo, Adebowale A.
Unknown Affiliation
Adoue, Véronique
Unknown Affiliation
Ambrosone, Christine B.
Unknown Affiliation
Atwood, Larry D.
Unknown Affiliation
Bandera, E. V.
Unknown Affiliation
Becker, Lewis C.
Unknown Affiliation
Berndt, Sonja I.
Unknown Affiliation
Bernstein, Leslie R.
Unknown Affiliation
Blot, William James
Unknown Affiliation
Boerwinkle, Eric A.
Unknown Affiliation
Britton, Angela F.
Unknown Affiliation
Casey, Graham R.
Unknown Affiliation
Chanock, Stephen J.
Unknown Affiliation
Demerath, Ellen W.
Unknown Affiliation
Deming, Sandra L.
Unknown Affiliation
Diver, William Ryan
Unknown Affiliation
Fox, Caroline S.
Unknown Affiliation
Harris, Tamara B.
Unknown Affiliation
Hernandez, Dena G.
Unknown Affiliation
Hu, Jennifer J.
Unknown Affiliation
Ingles, Sue Ann
Unknown Affiliation
John, Esther M.
Unknown Affiliation
Johnson, William Craig
Unknown Affiliation
Keating, Brendan J.
Unknown Affiliation
Kittles, Rick A.
Unknown Affiliation
Kolonel, Laurence N.
Unknown Affiliation
Kritchevsky, Stephen B.
Unknown Affiliation
Le Marchand, Loic̈
Unknown Affiliation
Lohman, Kurt K.
Unknown Affiliation
Liu, Jiankang
Unknown Affiliation
Millikan, Robert C.
Unknown Affiliation
Murphy, Adam Bryant
Unknown Affiliation
Musani, Solomon K.
Unknown Affiliation
Neslund-Dudas, Christine M.
Unknown Affiliation
North, Kari E.
Unknown Affiliation
Nyante, Sarah J.
Unknown Affiliation
Ogunniyi, Adesola O.
Unknown Affiliation
Ostrander, Elaine A.
Unknown Affiliation
Papanicolaou, George John
Unknown Affiliation
Patel, Sanjay R.
Unknown Affiliation
Pettaway, Curtis A.
Unknown Affiliation
Press, Michael F.
Unknown Affiliation
Redline, Susan S.
Unknown Affiliation
Rodriguez-Gil, Jorge L.
Unknown Affiliation
Rotimi, Charles N.
Unknown Affiliation
Rybicki, Benjamin A.
Unknown Affiliation
Salako, Babatunde Lawal
Unknown Affiliation
Schreiner, Pamela J.
Unknown Affiliation
Signorello, Lisa Beth
Unknown Affiliation
Singleton, Andrew B.
Unknown Affiliation
Stanford, Janet L.
Unknown Affiliation
Stram, Alex H.
Unknown Affiliation
Stram, Daniel O.
Unknown Affiliation
Strom, Sara S.
Unknown Affiliation
Suktitipat, Bhoom
Unknown Affiliation
Thun, Michael J.
Unknown Affiliation
Witte, John S.
Unknown Affiliation
Yanek, Lisa R.
Unknown Affiliation
Ziegler, Regina G.
Unknown Affiliation
Zheng, Wei
Unknown Affiliation
Xiaofeng, Zhu
Unknown Affiliation
Zmuda, Joseph M.
Unknown Affiliation
Zonderman, Alan B.
Unknown Affiliation
Evans, Michele Kim
Unknown Affiliation
Liu, Yongmei
Unknown Affiliation
Becker, Diane M.
Unknown Affiliation
Cooper, Richard S.
Unknown Affiliation
Pastinen, Tomi M.
Unknown Affiliation
Henderson, Brian E.
Unknown Affiliation
Hirschhorn, Joel N.
Unknown Affiliation
Lettre, Guillaume
Unknown Affiliation
Haiman, Christopher A.
Unknown Affiliation
Statistics
Citations: 80
Authors: 80
Affiliations: 45
Identifiers
Doi:
10.1371/journal.pgen.1002298
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Study Approach
Systematic review