Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
Biological Psychiatry, Volume 84, No. 9, Year 2018
Notification
URL copied to clipboard!
Description
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide. Results: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen's d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. Conclusions: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia. © 2018 Society of Biological Psychiatry
Authors & Co-Authors
van Erp, Theo G.M.
United States, Irvine
University of California, Irvine
Walton, Esther
United States, Atlanta
Georgia State University
Hibar, Derrek Paul
United States, Los Angeles
Keck School of Medicine of Usc
Belgium, Beerse
Janssen Research & Development
Schmaal, Lianne
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Jiang, Wenhao
United States, Atlanta
Georgia State University
Glahn, David C.
United States, New Haven
Yale University
United States, Hartford
Institute of Living
Pearlson, Godfrey David
United States, New Haven
Yale University
United States, Hartford
Institute of Living
Yao, Nailin
United States, New Haven
Yale University
United States, Hartford
Institute of Living
Fukunaga, Masaki
Japan, Okazaki
National Institutes of Natural Sciences - National Institute for Physiological Sciences
Hashimoto, Ryota
Japan, Suita
United Graduate School of Child Development
Japan, Suita
Graduate School of Medicine
Bustillo, Juan R.
United States, Albuquerque
The University of new Mexico
Clark, Vincent P.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
The Mind Research Network
Agartz, Ingrid A.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Sweden, Stockholm
Karolinska Institutet
Mueller, Bryon A.
United States, Minneapolis
University of Minnesota Twin Cities
Cahn, Wiepke
Netherlands, Utrecht
University Medical Center Utrecht
de Zwarte, Sonja M.C.
Netherlands, Utrecht
University Medical Center Utrecht
Hulshoff Pol, Hilleke E.
Netherlands, Utrecht
University Medical Center Utrecht
Kahn, René S.
Netherlands, Utrecht
University Medical Center Utrecht
Ophoff, Roel A.
United States, Los Angeles
University of California, Los Angeles
Netherlands, Utrecht
University Medical Center Utrecht
van Haren, Neeltje E.M.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Utrecht
University Medical Center Utrecht
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Dale, Anders M.
United States, San Diego
Center for Translational Imaging and Precision Medicine
United States, La Jolla
University of California, San Diego
Doan, Nhat Trung
Norway, Oslo
Universitetet I Oslo
Gurholt, Tiril P.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Hartberg, Cecilie Bhandari
Norway, Oslo
Universitetet I Oslo
Haukvik, Unn Kristin
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Jørgensen, Kjetil Nordbø
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Lagerberg, Trine Vik
Norway, Oslo
Oslo Universitetssykehus
Melle, Ingrid S.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Westlye, Lars T.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Gruber, Oliver
Germany, Heidelberg
Universitätsklinikum Heidelberg
Germany, Gottingen
Georg-august-universität Göttingen
Kraemer, Bernd
Germany, Heidelberg
Universitätsklinikum Heidelberg
Germany, Gottingen
Georg-august-universität Göttingen
Richter, Anja
Germany, Heidelberg
Universitätsklinikum Heidelberg
Germany, Gottingen
Georg-august-universität Göttingen
Calhoun, Vince D.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
The Mind Research Network
Crespo-Facorro, Benedicto
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Roiz-Santiáñez, Roberto
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Tordesillas-Gutiérrez, Diana
Spain, Santander
Universidad de Cantabria
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Loughland, Carmel Maree
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Carr, Vaughan James
Australia, Clayton
Monash University
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Catts, Stanley Victor
Australia, Brisbane
The University of Queensland
Cropley, Vanessa Louise
Australia, Melbourne
University of Melbourne
Fullerton, Janice M.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Green, Melissa J.
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Sydney
Neuroscience Research Australia
Henskens, Frans Alexander
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Jablensky, Assen Verniaminov
Australia, Perth
The University of Western Australia
Lenroot, Rhoshel K.
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Sydney
Neuroscience Research Australia
Mowry, Bryan J.
Australia, Brisbane
The University of Queensland
Michie, Patricia Therese
Australia, Callaghan
The University of Newcastle, Australia
Pantelis, Christos S.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Quidé, Yann
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Sydney
Neuroscience Research Australia
Schall, Ulrich
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Scott, Rodney J.
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Cairns, Murray J.
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Seal, Marc L.
Australia, Melbourne
Murdoch Children's Research Institute
Tooney, Paul A.
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Rasser, Paul E.
Australia, Callaghan
The University of Newcastle, Australia
Cooper, Gavin J.
Australia, Callaghan
The University of Newcastle, Australia
Shannon Weickert, Cynthia
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Sydney
Neuroscience Research Australia
Weickert, Thomas W.
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Sydney
Neuroscience Research Australia
Morris, Derek W.
Ireland, Galway
University of Galway
Ireland, Dublin
Trinity College Dublin
Hong, Liyi Elliot
United States, Baltimore
Maryland Psychiatric Research Center
Kochunov, Peter V.
United States, Baltimore
Maryland Psychiatric Research Center
Beard, Lauren M.
United States, Philadelphia
University of Pennsylvania
Gur, Raquel E.
United States, Philadelphia
University of Pennsylvania
Gur, Ruben C.
United States, Philadelphia
University of Pennsylvania
Satterthwaite, Theodore Daniel
United States, Philadelphia
University of Pennsylvania
Wolf, Daniel H.
United States, Philadelphia
University of Pennsylvania
Brown, Gregory G.
United States, La Jolla
University of California, San Diego
Ford, Judith M.
United States, San Francisco
University of California, San Francisco
United States, San Francisco
San Francisco va Health Care System
MacCiardi, Fabio
United States, Irvine
University of California, Irvine
Mathalon, Daniel H.
United States, San Francisco
University of California, San Francisco
United States, San Francisco
San Francisco va Health Care System
Potkin, Steven G.
United States, Irvine
University of California, Irvine
Preda, Adrian
United States, Irvine
University of California, Irvine
Lim, Kelvin O.
United States, Minneapolis
University of Minnesota Twin Cities
McEwen, Sarah Jacobson
United States, Los Angeles
University of California, Los Angeles
Yang, Fude
China, Beijing
Beijing Huilongguan Hospital
Tan, Shuping
China, Beijing
Beijing Huilongguan Hospital
Wang, Zhiren
China, Beijing
Beijing Huilongguan Hospital
Fan, Fengmei
China, Beijing
Beijing Huilongguan Hospital
Chen, Jingxu
China, Beijing
Beijing Huilongguan Hospital
Xiang, Hong
China, Chongqing
Chongqing Three Gorges University
Guo, Hua
China
Zhumadian Psychiatry Hospital
Ehrlich, Stefan
United States, Boston
Massachusetts General Hospital
Germany, Dresden
Technische Universität Dresden
Sponheim, Scott R.
United States, Minneapolis
University of Minnesota Twin Cities
United States, Minneapolis
Va Midwest Health Care Network
de Haan, Lieuwe
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Koenders, Laura
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
MacHielsen, Marise W.J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Amelsvoort, Thérèse A.M.J.
Netherlands, Maastricht
Universiteit Maastricht
Veltman, Dick J.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Assogna, Francesca
Italy, Rome
Irccs Fondazione Santa Lucia
Italy, Rome
Museo Storico Della Fisica e Centro Studi e Ricerche Enrico Fermi
Banaj, Nerisa
Italy, Rome
Irccs Fondazione Santa Lucia
de Rossi, Pietro
Italy, Rome
Irccs Fondazione Santa Lucia
Italy, Rome
Sapienza Università Di Roma
Iorio, Mariangela
Italy, Rome
Irccs Fondazione Santa Lucia
Piras, Fabrizio
Italy, Rome
Irccs Fondazione Santa Lucia
Italy, Rome
Museo Storico Della Fisica e Centro Studi e Ricerche Enrico Fermi
Spalletta, Gianfranco
United States, Houston
Baylor College of Medicine
Italy, Rome
Irccs Fondazione Santa Lucia
Pomarol-Clotet, Edith
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Salvador, Raymond
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Corvin, Aiden P.
Ireland, Dublin
Trinity College Dublin
Donohoe, Gary J.
Ireland, Galway
University of Galway
Ireland, Dublin
Trinity College Dublin
Kelly, Sinéad M.
United States, Boston
Beth Israel Deaconess Medical Center
United States, Boston
Harvard Medical School
Whelan, Christopher D.
United States, Los Angeles
Keck School of Medicine of Usc
Dickie, Erin W.
Canada, Toronto
Centre for Addiction and Mental Health
Voineskos, Aristotle N.
Canada, Toronto
Centre for Addiction and Mental Health
Ciufolini, Simone
United Kingdom, London
King's College London
Radua, Joaquim
Sweden, Stockholm
Karolinska Institutet
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
United Kingdom, London
King's College London
Dazzan, Paola
United Kingdom, London
King's College London
United Kingdom, Royston
National Institute for Health and Care Research
Murray, Robin M.
United Kingdom, London
King's College London
Marques, Tiago R.
United Kingdom, London
King's College London
Simmons, Andrew
United Kingdom, London
King's College London
Borgwardt, Stefan J.
Switzerland, Basel
Universitat Basel
Riecher-Rössler, Anita
Switzerland, Basel
Universitat Basel
Alpert, Kathryn I.
United States, Chicago
Northwestern University Feinberg School of Medicine
Wang, Lei E.
United States, Chicago
Northwestern University Feinberg School of Medicine
Jönsson, Erik Gunnar
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Bertolino, Alessandro
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Bonvino, Aurora
Italy, San Giovanni Rotondo
Irccs Casa Sollievo Della Sofferenza
Di Giorgio, Annabella
Italy, San Giovanni Rotondo
Irccs Casa Sollievo Della Sofferenza
Mayer, Andrew R.
United States, Albuquerque
The Mind Research Network
Stephen, Julia M.
United States, Albuquerque
The Mind Research Network
Kwon, Junsoo
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University
Yun, Je-yeon
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University Hospital
Cannon, Dara M.
Ireland, Galway
University of Galway
McDonald, Colm D.
Ireland, Galway
University of Galway
Lebedeva, Irina S.
Russian Federation, Moscow
Federal State Budget Scientific Institution Scientific Center of Mental Health
Tomyshev, Alexander S.
Russian Federation, Moscow
Federal State Budget Scientific Institution Scientific Center of Mental Health
Kaleda, Vasilii G.
Russian Federation, Moscow
Federal State Budget Scientific Institution Scientific Center of Mental Health
Engberg, Göran
Unknown Affiliation
Červenka, Simon
Unknown Affiliation
Schwieler, Lilly
Unknown Affiliation
Piehl, Fredrik
Unknown Affiliation
Busatto Filho, G. Filho
Brazil, Sao Paulo
Universidade de São Paulo
Rosa, Pedro Gomes Penteado
Brazil, Sao Paulo
Universidade de São Paulo
Serpa, Mauricio Henriques
Brazil, Sao Paulo
Universidade de São Paulo
Zanetti, M. V.
Brazil, Sao Paulo
Universidade de São Paulo
Höschl, Cyril
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Škoch, Antonín
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Czech Republic, Prague
Institutu Klinické a Experimentální Medicíny
Španiel, Filip A.
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Tomecek, David
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Czech Republic, Prague
Institute of Computer Science of the Academy of Sciences of the Czech Republic
Czech Republic, Prague
Czech Technical University in Prague
Hagenaars, Saskia P.
United Kingdom, Edinburgh
The University of Edinburgh
McIntosh, Andrew M.
United Kingdom, Edinburgh
The University of Edinburgh
Whalley, Heather Clare
United Kingdom, Edinburgh
The University of Edinburgh
Lawrie, Stephen M.
United Kingdom, Edinburgh
The University of Edinburgh
Knöchel, Christian
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Oertel-Knöchel, Viola
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Stäblein, Michael
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Howells, Fleur Margaret
South Africa, Cape Town
University of Cape Town
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Temmingh, Henk S.
South Africa, Cape Town
University of Cape Town
Uhlmann, Anne
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
López-Jaramillo, Carlos Alberto
Colombia, Medellin
Universidad de Antioquia
Dima, Danai
United Kingdom, London
King's College London
United Kingdom, London
City, University of London
Faskowitz, Joshua I.
United States, Los Angeles
Keck School of Medicine of Usc
Gutman, Boris A.
United States, Chicago
Illinois Institute of Technology
Jahanshad, Neda
United States, Los Angeles
Keck School of Medicine of Usc
Thompson, Paul M.
United States, Los Angeles
Keck School of Medicine of Usc
Turner, Jessica A.
United States, Atlanta
Georgia State University
United States, Albuquerque
The Mind Research Network
Statistics
Citations: 445
Authors: 156
Affiliations: 91
Identifiers
Doi:
10.1016/j.biopsych.2018.04.023
ISSN:
00063223
Research Areas
Genetics And Genomics
Mental Health
Study Design
Case-Control Study
Study Approach
Systematic review
Participants Gender
Male