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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Invasive pneumococcal disease in children >5 years of age in rural Mozambique
Tropical Medicine and International Health, Volume 11, No. 9, Year 2006
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Description
Objectives: To estimate the incidence and epidemiological characteristics of invasive pneumococcal disease (IPD) in children <5 years of age living in a rural area of southern Mozambique. Methods: As part of the clinical management of children admitted to Manhiça District Hospital, prospective surveillance for invasive bacterial disease was conducted from June 2001 to May 2003. The level of antibiotic resistance of the isolates was also analysed. Results: Pneumococcus was the most commonly isolated bacterium, accounting for 212 episodes. The estimated crude incidence rate of IPD in the study area among children <5 years of age was 416/100 000 per child-year at risk. The youngest age group (<3 months) had the highest incidence (779/100 000). Cases were detected during both rainy and dry seasons. The most common clinical diagnosis was pneumonia, made in 146/212 (69%) of the episodes of IPD. The overall case fatality rate was 10%, being highest among children with pneumococcal meningitis (5/9 = 56%). Pneumococcal isolates were highly susceptible to penicillin (86% susceptible and 14% with intermediate resistance) and chloramphenicol (98% susceptible). In contrast, up to 37% of the isolates tested were non-susceptible to cotrimoxazole. Conclusions: Incidence rates of IPD and associated mortality shown in this study highlight the need for pneumococcal vaccines in rural Africa, which must be effective in infants and young children. © 2006 Blackwell Publishing Ltd.
Authors & Co-Authors
Roca, Anna
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Sigaúque, Betuel
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Quintò, Llorenç L.
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Vallès, Xavier
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Espasa Soley, Mateu
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Abacassamo, Fátima
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Universidade Eduardo Mondlane
Sacarlal, J.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Universidade Eduardo Mondlane
MacEte, Eusébio V.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Nhacolo, Ariel Q.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Levine, Myron M.
United States, Baltimore
University of Maryland, Baltimore Umb
Alonso, Pedro Luís
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Statistics
Citations: 76
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2006.01697.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Mozambique