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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs
Epigenetics, Volume 9, No. 1, Year 2014
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Description
Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic regulators of gene transcription. The diversity and complexity of lncRNA genes means that they exert their regulatory effects by a variety of mechanisms. Although there is still much to be learned about the mechanism of lncRNA function, general principles are starting to emerge. In particular, the application of high throughput (deep) sequencing methodologies has greatly advanced our understanding of lncRNA gene function. lncRNAs function as adaptors that link specific chromatin loci with chromatin-remodeling complexes and transcription factors. lncRNAs can act in cis or trans to guide epigenetic-modifier complexes to distinct genomic sites, or act as scaffolds which recruit multiple proteins simultaneously, thereby coordinating their activities. In this review we discuss the genomic organization of lncRNAs, the importance of RNA secondary structure to lncRNA functionality, the multitude of ways in which they interact with the genome, and what evolutionary conservation tells us about their function. © 2014 Landes Bioscience.
Authors & Co-Authors
Roberts, Thomas C.
United States, San Diego
Scripps Research Institute
United Kingdom, Oxford
University of Oxford
Morris, Kevin V.
United States, San Diego
Scripps Research Institute
Australia, Sydney
Unsw Sydney
Weinberg, Marc S.
United States, San Diego
Scripps Research Institute
South Africa, Johannesburg
School of Pathology
Statistics
Citations: 125
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.4161/epi.26700
ISSN:
15592294
e-ISSN:
15592308
Research Areas
Genetics And Genomics