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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks
Archives of Virology, Volume 156, No. 1, Year 2011
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Description
Domestic ducks have been implicated in the dissemination and evolution of H5N1 highly pathogenic avian influenza (HPAI) viruses. In this study, two H5N1 HPAI viruses belonging to clade 2.2.1 isolated in Egypt in 2007 and 2008 were analyzed for their pathogenicity in domestic Pekin ducks. Both viruses produced clinical signs and mortality, but the 2008 virus was more virulent, inducing early onset of neurological signs and killing all ducks with a mean death time (MDT) of 4.1 days. The 2007 virus killed 3/8 ducks with a MDT of 7 days. Full-genome sequencing and phylogenetic analysis were used to examine differences in the virus genes that might explain the differences observed in pathogenicity. The genomes differed in 49 amino acids, with most of the differences found in the hemagglutinin protein. This increase in pathogenicity in ducks observed with certain H5N1 HPAI viruses has implications for the control of the disease, since vaccinated ducks infected with highly virulent strains shed viruses for longer periods of time, perpetuating the virus in the environment and increasing the possibility of transmission to susceptible birds. © 2010 US Government.
Authors & Co-Authors
Wasilenko, J. L.
United States, Washington, D.c.
Usda Agricultural Research Service
Arafa, Abdel Satar A.
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Selim, Abdullah A.
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Hassan, Mohammed Ismail
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Aly, Mona Meherez
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Ali, Abdel Hakem M.
Egypt, Abbassia
The Central Laboratory for Evaluation of Veterinary Biologics Clevb
Nassif, Samir A.
Egypt, Abbassia
The Central Laboratory for Evaluation of Veterinary Biologics Clevb
Elebiary, E.
Egypt, Abbassia
The Central Laboratory for Evaluation of Veterinary Biologics Clevb
Balish, Amanda L.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Klimov, Alexander I.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Suarez, David L.
United States, Washington, D.c.
Usda Agricultural Research Service
Swayne, David E.
United States, Washington, D.c.
Usda Agricultural Research Service
Pantin-Jackwood, M.
United States, Washington, D.c.
Usda Agricultural Research Service
Statistics
Citations: 33
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1007/s00705-010-0813-y
ISSN:
03048608
Study Locations
Egypt