Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Leukotrienes in the pathophysiology of kwashiorkor
The Lancet, Volume 342, No. 8877, Year 1993
Notification
URL copied to clipboard!
Description
Summary. The actions of cysteinyl leukotrienes include production of oedema. We investigated whether these mediators might be involved in the oedematous malnutrition syndrome kwashiorkor. The capacity of leukotriene (LT) synthesis by stimulated whole blood and urinary LTE4 excretion was measured in 12 children with kwashiorkor, and compared with that in 24 marasmic and 12 control children. Urinary LTE4 excretion was significantly higher in patients with kwashiorkor than in controls (118·8 [SD 28 5] vs 31 1 [19·3] nmol/mol creatinine; p<0 01). Whole blood LTE4 synthesis was increased in kwashiorkor patients by a factor of 3·5 (p<0 01). In marasmic children, LTE4 excretion and synthesis did not differ from those in controls. Although glutathione, known to participate in LTC4 synthesis, was subnormal in erythrocytes of all malnourished patients, whole-blood LTC4 synthesis was higher in kwashiorkor patients than in controls (28·1 [5·0] ng/mL; p<0·05), and close to control values (9 8 [1 5] ng/mL) in marasmic children. LTB4 synthesis, however, was greatly reduced in kwashiorkor patients (11·5 [2·4] vs 46·5 [6 4] ng/mL; p<0 01). Inability to synthesise the immunoregulator LTB4 may lead to inefficient chemoattraction of phagocytes and an inadequate inflammatory response in kwashiorkor. The increased endogenous cysteinyl LT generation in kwashiorkor suggests that these lipid mediators are involved in the pathophysiology of the syndrome, particulary in oedema formation. Lancet 1993; 342: 958-60. © 1993.
Authors & Co-Authors
Mayatepek, Ertan
Germany, Heidelberg
Universitätsklinikum Heidelberg
Becker, Katja
Germany, Heidelberg
Universitätsklinikum Heidelberg
Hoffmann, G. F.
Germany, Heidelberg
Universitätsklinikum Heidelberg
Leichsenring, Michael
Germany, Heidelberg
Universitätsklinikum Heidelberg
Gana, Lawan
Nigeria, Yola
Specialist Hospital Yola, Nigeria
Statistics
Citations: 48
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/0140-6736(93)92003-C
ISSN:
01406736
Research Areas
Food Security
Maternal And Child Health