Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metronidazole metabolism following oral benzoylmetronidazole suspension in children with giardiasis
Journal of Antimicrobial Chemotherapy, Volume 18, No. 2, Year 1986
Notification
URL copied to clipboard!
Description
A suspension of benzoylmetronidazole (6.4% w/v) was given orally at a dose of 15-25 ml, equivalent to 0.6-1 g metronidazole, once a day for three days to 11 children with giardiasis. Blood samples were collected after the first and third doses for analysis of plasma metronidazole and its main oxidative metabolite by high performance liquid chromatography. Peak metronidazole concentrations were 22.60±8.52 mg/l (mean±S.D.) after the first dose, and 30.22±10.06 mg/1 after the third dose, occurring at 3.6±1.4 and 4.4±2.9 hours post-dose, respectively. Peak concentrations of the metabolite were 4.26±1.94 mg/l after the first dose and 7.96±3.63 mg/1 after the third dose, occurring 7.2±1.6 and 9.1±3.3 h post-dose, respectively. Calculation of plasma metronidazole half-life and clearance values was not possible.This study shows that oral administration of metronidazole as its benzoyl ester slows the rate of metronidazole absorption, followed by sustained plasma concentrations and a prolonged elimination phase. Giardiasis does not appear to prevent metronidazole absorption. Concurrent giardiasis is unlikely to influence metronidazole therapy for systemic anaerobic infections. © 1986, by The British Society for Antimicrobial Chemotherapy.
Authors & Co-Authors
Homeida, Mamoun M.A.
Unknown Affiliation
Daneshmend, Tawfique K.
Unknown Affiliation
Ali, Hassan M.A.
Unknown Affiliation
Kaye, Clive M.
Unknown Affiliation
Statistics
Citations: 7
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1093/jac/18.2.213
ISSN:
03057453
Research Areas
Cancer
Health System And Policy
Maternal And Child Health