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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Randomized trial of early developmental intervention on outcomes in children after birth asphyxia in developing countries
Journal of Pediatrics, Volume 162, No. 4, Year 2013
Notification
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Description
Objective: To determine if early developmental intervention (EDI) improves developmental abilities in resuscitated children. Study design: This was a parallel group, randomized controlled trial of infants unresponsive to stimulation who received bag and mask ventilation as part of their resuscitation at birth and infants who did not require any resuscitation born in rural communities in India, Pakistan, and Zambia. Intervention infants received a parent-implemented EDI delivered with home visits by parent trainers every other week for 3 years starting the first month after birth. Parents in both intervention and control groups received health and safety counseling during home visits on the same schedule. The main outcome measure was the Mental Development Index (MDI) of the Bayley Scales of Infant Development, 2nd edition, assessed at 36 months by evaluators unaware of treatment group and resuscitation history. Results: MDI was higher in the EDI (102.6 ± 9.8) compared with the control resuscitated children (98.0 ± 14.6, 1-sided P = .0202), but there was no difference between groups in the nonresuscitated children (100.1 ± 10.7 vs 97.7 ± 10.4, P = .1392). The Psychomotor Development Index was higher in the EDI group for both the resuscitated (P = .0430) and nonresuscitated children (P = .0164). Conclusions: This trial of home-based, parent provided EDI in children resuscitated at birth provides evidence of treatment benefits on cognitive and psychomotor outcomes. MDI and Psychomotor Development Index scores of both nonresuscitated and resuscitated infants were within normal range, independent of early intervention. © 2013 Mosby Inc.
Authors & Co-Authors
Carlo, Waldemar A.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Goudar, Shivaprasad S.
India, Belgaum
Jawaharlal Nehru Medical College Belgaum
Pasha, Omrana
Pakistan, Karachi
The Aga Khan University Hospital
Chomba, Elwyn Nachanya
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Zambia, Lusaka
University of Zambia
Wallander, Jan Lance
United States, Merced
Uc Merced
Biasini, Fred J.
United States, Birmingham
The University of Alabama at Birmingham
McClure, Elizabeth M.
United States, Research Triangle Park
Rti International
Thorsten, Vanessa R.
United States, Research Triangle Park
Rti International
Chakraborty, Hrishikesh
United States, Research Triangle Park
Rti International
United States, Columbia
University of South Carolina
Wallace, Dennis D.
United States, Research Triangle Park
Rti International
Shearer, Darlene L.
United States, Bowling Green
Western Kentucky University
Wright, Linda L.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Statistics
Citations: 51
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1016/j.jpeds.2012.09.052
ISSN:
00223476
e-ISSN:
10976833
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Study Approach
Quantitative
Study Locations
Zambia