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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coronary events in obese hemodialysis patients before and after renal transplantation
Clinical Transplantation, Volume 29, No. 11, Year 2015
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Description
We examined the impact of obesity (BMI ≥30 kg/m2, n = 357) on prognosis in 1696 hemodialysis (HD) patients before and after renal transplantation (TX). End-points were coronary events, composite cardiovascular (CV) events, and death. Obese HD patients were older (55.9 ± 9.2 vs. 54.2 ± 11), had more diabetes (54% vs. 40%), dyslipidemia (49% vs. 30%), altered myocardial scan (38% vs. 31%), myocardial infarction (MI) (16% vs. 10%), coronary intervention (11% vs. 7%), higher total cholesterol (186 ± 52 vs. 169 ± 47), and triglycerides (219 ± 167 vs. 144 ± 91). Obese undergoing TX had more dyslipidemia (46% vs. 31%), angina (23% vs. 14%), MI (18% vs. 5%), increased total cholesterol (185 ± 56 vs. 172 ± 48), and triglycerides (237 ± 190 vs. 149 ± 100). Obesity was independently associated with coronary events (log-rank = 0.008, HR 2.55% CI 1.27-5.11) and death (log-rank 0.046, HR 1.52, % CI 1.007-2.30) in TX but not in HD. Obese HD patients had more risk factors and ischemic heart disease, but these characteristics did not interfere with prognosis. In TX patients, obesity predicts coronary events and death. © 2015 John Wiley
Authors & Co-Authors
Galvão de Lima, José Jayme
Brazil, Sao Paulo
Universidade de São Paulo
Gowdak, Luís Henrique Wolff
Brazil, Sao Paulo
Universidade de São Paulo
De-Paula, Flávio Jota
Brazil, Sao Paulo
Universidade de São Paulo
Muela, Henrique C.S.
Brazil, Sao Paulo
Universidade de São Paulo
Angola, Luanda
University Agostinho Neto
David-Neto, Elias
Brazil, Sao Paulo
Universidade de São Paulo
Bortolotto, Luiz Aparecido
Brazil, Sao Paulo
Universidade de São Paulo
Statistics
Citations: 6
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/ctr.12616
ISSN:
09020063
e-ISSN:
13990012
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial