Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of alpha chain disease. Results of a prospective study in 21 Tunisian patients by the Tunisian‐French intestinal lymphoma study group
Cancer, Volume 63, No. 7, Year 1989
Notification
URL copied to clipboard!
Description
Between 1981 and 1985, the authors studied 21 Tunisian patients with alpha chain disease. Twenty of 21 underwent laparotomy. According to Galian et al. six patients were classified Stage A, two Stage B, and 13 Stage C. The therapeutic regimen included the following: (1) Antibiotics: In the case of intestinal bacterial overgrowth (IBO), antibiotics selected by their antibiograms were delivered; in absence of IBO, metronidazole plus ampicillin were first given. The antibiotic treatment was changed in case of therapeutic failure. (2) Chemotherapy: From 1981 to 1983 a cyclophosphamide, Adriamycin (doxorubicin), teniposide (VM‐26), prednisone (CHVP) protocol (Adriamycin 35 mg/m2, teniposide 50 mg/m2 day 2, cyclophosphamide 300 mg/m2 days 2 through 4, prednisone 40 mg/m2 days 1 through 10) was used. After 1983 bleomycine 15 mg, Adriamycin 30 mg, vinblastine 10 mg were given on day 15. Serum immunoelectrophoresis and immunohistochemical study of duodenojejunal specimens were made on a 3‐month and 6‐month basis, respectively. Survival curve analysis was made according to Kaplan and Meier. Results were as follows: (1) Stage A: Six patients were first treated by antibiotics alone; two complete responses (CR) persisting 42 and 55 months later were observed, respectively. The four antibiotic failures were submitted to further chemotherapy with four subsequent failures and two deaths. (2) Stage B‐C: Chemotherapy led to nine CR with one precocious relapse, a salvage chemotherapy allowing to one more CR. (3) All stages mixed, percentage of survival reached 90 ± n 12% at 2 years and 67 ± n 25% at 3 years, all patients alive beyond 3.5 years being disease‐free. Copyright © 1989 American Cancer Society
Authors & Co-Authors
Ben-Ayed, Farhat
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Halphen, Marc
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Najjar, Taoofik
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Boussene, H.
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Jaàfoura, Habib Mohamed
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Bouguerra, Annie
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Ben Salah, Nozha
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Mourali, Nejib
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Ayed, Khaled
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Ben Khalifa, H.
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Garoui, H.
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Gargouri, M.
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Tufrali, G.
Tunisia, Tunis
Groupe Tuniso-francais D'etude Des Lymphomes Intestinaux Tufrali Groupe
Statistics
Citations: 99
Authors: 13
Affiliations: 1
Identifiers
Doi:
10.1002/1097-0142(19890401)63:7<1251::AID-CNCR2820630704>3.0.CO;2-H
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Design
Cohort Study