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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Aetiology of AIDS - Antibodies to human T-cell leukaemia virus (type III) in haemophiliacs
Nature, Volume 312, No. 5992, Year 1984
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Description
Human T-cell leukaemia virus type III (HTLV-III) is suspected of having a key role in the pathogenesis of acquired immune deficiency syndrome (AIDS) 1-4. Epidemiological data suggest that AIDS is transmitted by an infectious agent through intimate contact with body secretions, blood or blood products5. To maintain haemostasis, many haemophiliac patients depend on commercially prepared clotting concentrates made from large multi-donor plasma pools and are thus at increased risk of developing the disease 6,7. We report here that, using indirect membrane immunofluorescence and radioimmunoprecipitation with SDS-polyacrylamide gel electrophoresis, we have detected antibodies to HTLV-III in 30 of 47 (64%) asymptomatic haemophiliacs and in all of three haemophiliacs who either had or soon developed AIDS. Of 34 samples drawn before 1984, 18 (53%) were antibody-positive, whereas of 16 samples drawn during 1984, 15 (94%) were positive (P≤ 0.002). These data suggest that exposure to HTLV-III antigens is widespread among asymptomatic haemophiliacs. © 1984 Nature Publishing Group.
Authors & Co-Authors
Barin, Françis
United States, Boston
Harvard T.h. Chan School of Public Health
Sullivan, John L.
United States, Worcester
University of Massachusetts Chan Medical School
United States, Worcester
Umass Memorial Medical Center
McLane, Mary Fran
United States, Boston
Harvard T.h. Chan School of Public Health
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 125
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1038/312367a0
ISSN:
00280836
Research Areas
Infectious Diseases