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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diffusion-weigted MRI in cortical ischaemia
Neuroradiology, Volume 46, No. 3, Year 2004
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Description
We carried out MRI on 16 male and three female comatose patients, aged 2 days to 79 years, with suspected cortical ischaemia referred from our intensive care units. Using a head coil, and following standard imaging, including coronal fluid-attenuated inversion-recovery images, we performed diffusion-weighted imaging (DWI) using a whole-brain multislice single-shot echo-planar sequence with b 0 and 1000 s/mm2: 5-mm slices covering the whole brain, TR 7000 TE 106 ms, 128×128 pixels, field of view 250 mm, one excitation. Maps of apparent diffusion coefficients (ADC) were generated automatically. DWI showed cortical, basal ganglia and watershed-area high signal in all cases, associated with a decrease in ADC to 60- 80% of normal. DWI showed lesions not seen (40%) or underestimated (40%) on conventional T2-weighted imaging. Within 24 h of the onset of symptoms, DWI showed changes not readily detectable on T2-weighted images. The cortical high signal on DWI and the ADC changes, suggesting severe ischaemia rather than oedema, was found in areas known to be affected by cortical laminar necrosis. Extension to the brain stem and white matter was associated with a higher likelihood of death. © Springer-Verlag 2004.
Authors & Co-Authors
Lövblad, Karl Olof
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Wetzel, S. G.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Somon, T.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Wilhelm, K.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Mehdizade, A.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Kelekis, A.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
El-Koussy, Marwan Mohamed
Switzerland, Bern
University of Bern
Egypt, Giza
Cairo University
El-Tatawy, Samir A.M.
Egypt, Giza
Cairo University
Bishof, M.
Switzerland, Bern
University of Bern
Schroth, Gerhard
Switzerland, Bern
University of Bern
Perrig, S.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Lazeyras, F.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Sztajazel, R.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Terrier, F.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Rüfenacht, D.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Delavelle, J.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Statistics
Citations: 31
Authors: 16
Affiliations: 3
Identifiers
Doi:
10.1007/s00234-003-1133-7
Participants Gender
Male
Female