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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranes
FEBS Open Bio, Volume 3, Year 2013
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Description
Rat erythrocytes, or erythrocyte membrane ghosts, have been subjected to either chronic (drinking water containing 15 mM lead acetate for 3 months) or acute (10-9-10-2 M lead acetate for 1 h) Pb2+ treatments and subsequent changes in membrane properties have been measured. Pb2+ concentration in chronically treated rat plasma was 1.8 μM, which is one order of magnitude above normal values. Membrane permeability, or hemolysis, was increased in both cases. A comparative study using liposomes, in the form of large unilamellar vesicles, also indicated an increase in membrane permeability. Membrane microviscosity, or acyl chain molecular order, measured as DPH fluorescence polarization, showed an increased order in the acute treatments, at least below 700 μM Pb2+, and a similar increase in chronically treated rats. The correlation between acute and chronic treatments, and between cell and model membranes, suggests that the present observations may be relevant in the pathogenesis of lead intoxication in humans. © 2013 The Authors.
Authors & Co-Authors
Ahyayauch, Hasna
Spain, Leioa
Universidad Del Pais Vasco
Morocco, Agdal Rabat
Institut de Formation Aux Carrieres de Sante de Rabat Ifcsr
Sansar, Wafae
Morocco, Marakech
Faculté Des Sciences Semlalia
Rendón-Ramírez, Adela
Spain, Leioa
Universidad Del Pais Vasco
Goñi, Félix María
Spain, Leioa
Universidad Del Pais Vasco
Bennouna, Mohammed Abdouh
Morocco, Marakech
Faculté Des Sciences Semlalia
Gamrani, Halima
Morocco, Marakech
Faculté Des Sciences Semlalia
Statistics
Citations: 19
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.fob.2013.04.001
ISSN:
22115463
Research Areas
Environmental