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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reversal of IFN-γ, oxLDL and prolactin serum levels correlate with clinical improvement in patients with peripartum cardiomyopathy
European Journal of Heart Failure, Volume 10, No. 9, Year 2008
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Description
Aim: Peripartum cardiomyopathy (PPCM) is characterized by acute onset of heart failure of unknown aetiology. We aimed to identify mechanisms involved in initiation and progression of the disease. Methods and results: Serum markers related to cardiac function, apoptosis, oxidative stress, remodelling, inflammation and the nursing hormone prolactin were analyzed in PPCM patients and healthy controls. The kinetics of these markers were compared between patients who improved cardiac function (IMP) and those patients who did not improve (NIMP), over 6 months follow-up. All patients received ACE-inhibitors, beta-blockers and diuretics. Baseline levels of TGF-beta-1 were significantly lower, MMP-9 and VEGF were not different; all other markers were significantly higher in PPCM compared with controls. Only baseline NT-proBNP levels were higher in NIMP compared with IMP. After 6 months, NT-proBNP, oxLDL and IFN-γ were significantly lower in IMP and the decrease in oxLDL, IFN-γ and prolactin was significant in IMP but not in NIMP. Significant correlations were observed between the kinetics of NT-proBNP, oxLDL, prolactin and IFN-γ in PPCM patients. Conclusion: Baseline NT-proBNP and the failure to decrease oxLDL, IFN-γ and prolactin are associated with poor outcome in PPCM, suggesting a potential role of these factors in the pathophysiology of PPCM and for risk stratification of PPCM patients. © 2008 European Society of Cardiology.
Authors & Co-Authors
Förster, Olaf
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Ansari, Aftab Ab A.
United States, Atlanta
Emory University School of Medicine
Sundstrom, J. Bruce
United States, Atlanta
Emory University School of Medicine
Libhaber, Elena N.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Tshani, Winnie
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Becker, Anthony C.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Yip, Anthony
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Klein, Gunnar
Germany, Hannover
Hannover Medical School
Sliwa, Karen S.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Statistics
Citations: 183
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejheart.2008.07.005
ISSN:
13889842
Research Areas
Cancer
Noncommunicable Diseases
Study Design
Cohort Study