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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Parvovirus B19 infection in the first trimester of pregnancy and risk of fetal loss: A population-based case-control study
American Journal of Epidemiology, Volume 176, No. 9, Year 2012
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Description
Because parvovirus B19 infection during pregnancy has been associated with increased risk of fetal loss in small or selected study populations, the authors evaluated the risk in a population-based study. A nested case-control study was conducted by using a population-based screening for syphilis in 3 regions in Denmark from 1992 to 1994. Cases of women with fetal loss were identified in the National Patient Register (n 2,918), and control women with live-born children were identified in the Medical Birth Register (n 8,429) by matching on age and sampling week. First-trimester serum samples were tested for parvovirus B19 immunoglobulin M positivity. Parvovirus B19 immunoglobulin M positivity was associated with a 71 increased risk of fetal loss (odds ratio 1.71, 95 confidence interval: 1.02, 2.86). Adjustment for number of children or stratifying for gestational age at loss did not change the risk estimate. Assuming causality, only 0.1 of fetal losses were attributable to parvovirus B19 positivity, a proportion which could increase to approximately 1 during epidemic periods. In conclusion, acute parvovirus B19 infection during the first trimester of pregnancy was associated with an increased risk of fetal loss. However, the impact on the overall burden of fetal losses appeared small even during epidemics. © 2012 The Author.
Authors & Co-Authors
Pedersen, Carsten Bøcker
Denmark, Copenhagen
Statens Serum Institut
Aaby, Peter
Denmark, Copenhagen
Statens Serum Institut
Wohlfahrt, Jan
Denmark, Copenhagen
Statens Serum Institut
Melbye, Mads
Denmark, Copenhagen
Statens Serum Institut
Statistics
Citations: 26
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1093/aje/kws177
ISSN:
14766256
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female