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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Identification of host–pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank
Nature Communications, Volume 13, No. 1, Article 1818, Year 2022
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Description
Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents including human herpes, hepatitis, polyoma, papilloma, and retroviruses, as well as Chlamydia trachomatis, Helicobacter pylori and Toxoplasma gondii, then assayed a random subset of 9695 UK Biobank participants. We find seroprevalence estimates consistent with those expected from prior literature and confirm multiple associations of antibody responses with sociodemographic characteristics (e.g., lifetime sexual partners with C. trachomatis), HLA genetic variants (rs6927022 with Epstein-Barr virus (EBV) EBNA1 antibodies) and disease outcomes (human papillomavirus-16 seropositivity with cervical intraepithelial neoplasia, and EBV responses with multiple sclerosis). Our accessible dataset is one of the largest incorporating diverse infectious agents in a prospective UK cohort offering opportunities to improve our understanding of host-pathogen-disease relationships with significant clinical and public health implications. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8983701/bin/41467_2022_29307_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8983701/bin/41467_2022_29307_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8983701/bin/41467_2022_29307_MOESM3_ESM.pdf
Authors & Co-Authors
Mentzer, Alexander J.
United Kingdom, Oxford
University of Oxford
Brenner, Nicole
Germany, Heidelberg
German Cancer Research Center
Allen, Naomi E.
United Kingdom, Oxford
University of Oxford
Cortés, Adrián
United Kingdom, Oxford
University of Oxford
Almond, Rachael J.
Unknown Affiliation
McVean, Gil
United Kingdom, Oxford
University of Oxford
Aiello, Allison E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Bangham, Charles R.M.
United Kingdom, London
Imperial College London
Borrow, Ray
United Kingdom, London
Public Health England
Breuer, Judith M.
United Kingdom, London
University College London
Brooks, Tim J.G.
United Kingdom, London
Public Health England
Franceschi, Silvia F.
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Gkrania-Klotsas, Effrossyni
United Kingdom, Cambridge
University of Cambridge
Greenwood, Brian M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Guy, Edward C.
United Kingdom, Cardiff
Public Health Wales
Jeffery, Katie J.M.
United Kingdom, Oxford
John Radcliffe Hospital
Kelly, Dominic F.
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
van der Klis, Fiona Regina Maria
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Knight, Julian C.
United Kingdom, Oxford
University of Oxford
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Naranbhai, Vivek
United Kingdom, Oxford
University of Oxford
Pebody, Richard G.
United Kingdom, London
Public Health England
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
Schulz, Thomas Friedrich
Germany, Hannover
Gottfried Wilhelm Leibniz Universität Hannover
Taylor, Graham P.
United Kingdom, London
Imperial College London
Towers, Greg J.
United Kingdom, London
University College London
Tommasino, Massimo
France, Lyon
Centre International de Recherche Sur le Cancer
Whitby, Denise
United States, Reston
Leidos Inc.
Wild, Christopher Paul
France, Lyon
Centre International de Recherche Sur le Cancer
Wyllie, David H.
United Kingdom, Oxford
The Jenner Institute
Collins, Rory
United Kingdom, Oxford
University of Oxford
Hill, Adrian V.S.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Jenner Institute
Waterboer, Tim
Germany, Heidelberg
German Cancer Research Center
Statistics
Citations: 10
Authors: 34
Affiliations: 18
Identifiers
Doi:
10.1038/s41467-022-29307-3
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative